Basic Information
Regular Relationship :
Phenotype/DiseaseSpecieNon-Small Cell Lung Cancer
CeRNA1MALAT1[LncRNA]
miRNAmiR-124[miRNA]
CeRNA2STAT3[mRNA]
Tissue/Cell lineA549, H23, H522, H1299, H460, 16Hbe And Hek-293T
SpecieHomo sapiens (human)
CitationJ Cell Physiol 2018 Sep 233, 6679-6688 doi:10.1002/jcp.26325 PMID:29215698
Reference title
The lncRNA MALAT1 contributes to non-small cell lung cancer development via modulating miR-124/STAT3 axis.
Experimental verification
qPCR,Luciferase reporter assay,Western blot,RIP
Functional description
MALAT1 was significantly upregulated in five human NSCLC cells.On the contrary,miR-124 was remarkably downregulated, which indicated a potential negative correlation between miR-124 and MALAT1.MALAT1can act as a competing endogenous lncRNA (ceRNA) to modulate miR-124/STAT3 in NSCLC. MALAT1/miR-124/STAT3 was involved in NSCLC development.MALAT1 can have interactions with estrogen receptor and indicate poor survival of breast cancer.
Annotations
External Annotation for MALAT1 |
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LncRNA-associated competing triplets and functions. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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Infer genomic variations that disturb lncRNA-associated ceRNA regulation.. |
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Provide and annotate disease or phenotype-associated variants in human long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) or their regulatory elements. |
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Providing cellular-specific lncRNA-associated ceRNA networks predicted via high-throughput analysis of single-cell genomic data. |
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Information on all annotated and predicted human genes. |
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Gene nomenclature, gene families and associated resources (genomic, proteomic, phenotypic information). |
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Genome browser for vertebrate genomes. |
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An annotated collection of all publicly available DNA sequences. |
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A wiki-based platform for community curation of human long non-coding RNAs. |
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An integrated knowledge database dedicated to non-coding RNAs. |
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An integrated database of human annotated lncRNA transcripts. |
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Comprehensive annotations of eukaryotic long non-coding RNAs. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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A comprehensive, authoritative compendium of human genes and genetic phenotypes. |
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The catalogue of somatic mutations in cancer. |
