Basic Information
Regular Relationship :
Phenotype/DiseaseSpecieCervical Cancer
CeRNA1MALAT1[LncRNA]
miRNAmiR-143[miRNA]
CeRNA2E-cadherin[mRNA]
Tissue/Cell lineHela
SpecieHomo sapiens (human)
CitationGenet Mol Res 2017 Feb 23 16 doi:10.4238/gmr16019269 PMID:28252165
Reference title
Effects of miRNA-143 and the non-coding RNA MALAT1 on the pathogenesis and metastasis of HeLa cells.
Experimental verification
qPCR,RNAi,Western blot,MTT assay etc.
Functional description
The levels of MALAT1 were also significantly higher in the MALAT1 transfection group compared to the control group. Low levels of miRNA-143 and high levels of MALAT1 could potentiate proliferation of the cervical cancer cell line HeLa, and accelerate its invasion and migration via enhancement of vimentin and reduction of E-cadherin levels, respectively.
Annotations
External Annotation for MALAT1 |
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LncRNA-associated competing triplets and functions. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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Infer genomic variations that disturb lncRNA-associated ceRNA regulation.. |
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Provide and annotate disease or phenotype-associated variants in human long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) or their regulatory elements. |
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Providing cellular-specific lncRNA-associated ceRNA networks predicted via high-throughput analysis of single-cell genomic data. |
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Information on all annotated and predicted human genes. |
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Gene nomenclature, gene families and associated resources (genomic, proteomic, phenotypic information). |
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Genome browser for vertebrate genomes. |
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An annotated collection of all publicly available DNA sequences. |
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A wiki-based platform for community curation of human long non-coding RNAs. |
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An integrated knowledge database dedicated to non-coding RNAs. |
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An integrated database of human annotated lncRNA transcripts. |
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Comprehensive annotations of eukaryotic long non-coding RNAs. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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A comprehensive, authoritative compendium of human genes and genetic phenotypes. |
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The catalogue of somatic mutations in cancer. |
