Basic Information
Regular Relationship :
Phenotype/DiseaseSpecieHilar Cholangiocarcinoma
CeRNA1MALAT1[LncRNA]
miRNAmiR-204[miRNA]
CeRNA2CXCR4[mRNA]
Tissue/Cell lineHibepic, Rbe, Huh28, Frh0201, Qbc939, Snu-1196
SpecieHomo sapiens (human)
CitationJ Cell Biochem 2017 Nov 118, 3643-3653 doi:10.1002/jcb.25862 PMID:28059437
Reference title
Long Non-Coding RNA MALAT1 Interacted with miR-204 to Modulates Human Hilar Cholangiocarcinoma Proliferation, Migration and Invasion by Targeting CXCR4.
Experimental verification
qPCR,Western blot,Luciferase reporter assay,Cell proliferation assay etc.
Functional description
lncRNA-MALAT1 was specifically upregulated in HCCA tissues and cell lines,and was associated with pathological T stage, a larger tumor size and perineural invasion. Knockdown of MALAT1 inhibited the proliferation, migration and invasion of human HCCA cell. In addition, chemokine receptor-4 (CXCR4) was involved in MALAT1 induced human HCCA growth, migration and invasion.
Annotations
External Annotation for MALAT1 |
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LncRNA-associated competing triplets and functions. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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Infer genomic variations that disturb lncRNA-associated ceRNA regulation.. |
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Provide and annotate disease or phenotype-associated variants in human long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) or their regulatory elements. |
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Providing cellular-specific lncRNA-associated ceRNA networks predicted via high-throughput analysis of single-cell genomic data. |
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Information on all annotated and predicted human genes. |
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Gene nomenclature, gene families and associated resources (genomic, proteomic, phenotypic information). |
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Genome browser for vertebrate genomes. |
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An annotated collection of all publicly available DNA sequences. |
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A wiki-based platform for community curation of human long non-coding RNAs. |
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An integrated knowledge database dedicated to non-coding RNAs. |
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An integrated database of human annotated lncRNA transcripts. |
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Comprehensive annotations of eukaryotic long non-coding RNAs. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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A comprehensive, authoritative compendium of human genes and genetic phenotypes. |
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The catalogue of somatic mutations in cancer. |
