Basic Information
Regular Relationship :
Phenotype/DiseaseSpecieNA
CeRNA1mir-124 sponge[Artifically engineered RNA]
miRNAmiR-124[miRNA]
CeRNA2NA[mRNA]
Tissue/Cell lineHippocampal Neurons, Hek293T
SpecieHomo sapiens (human)
CitationNeuron 2010 Feb 11 65, 373-84 doi:10.1016/j.neuron.2010.01.005 PMID:20159450
Reference title
Regulation of synaptic structure and function by FMRP-associated microRNAs miR-125b and miR-132.
Experimental verification
Luciferase reporter assay;qRT-PCR
Functional description
We show that miR-125b and miR-132, as well as several other miRNAs, are associated with FMRP in mouse brain. miR-125b and miR-132 had largely opposing effects on dendritic spine morphology and synaptic physiology in hippocampal neurons. FMRP knockdown ameliorates the effect of miRNA overexpression on spine morphology. We identified NMDA receptor subunit NR2A as a target of miR-125b and show that NR2A mRNA is specifically associated with FMRP in brain. In hippocampal neurons, NR2A expression is negatively regulated through its 3 UTR by FMRP, miR-125b, and Argonaute 1. Regulation of NR2A 3UTR by FMRP depends in part on miR-125b
Annotations
External Annotation for mir-124 sponge |
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LncRNA-associated competing triplets and functions. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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Infer genomic variations that disturb lncRNA-associated ceRNA regulation.. |
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Provide and annotate disease or phenotype-associated variants in human long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) or their regulatory elements. |
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Providing cellular-specific lncRNA-associated ceRNA networks predicted via high-throughput analysis of single-cell genomic data. |
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Information on all annotated and predicted human genes. |
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Gene nomenclature, gene families and associated resources (genomic, proteomic, phenotypic information). |
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Genome browser for vertebrate genomes. |
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An annotated collection of all publicly available DNA sequences. |
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A wiki-based platform for community curation of human long non-coding RNAs. |
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An integrated knowledge database dedicated to non-coding RNAs. |
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An integrated database of human annotated lncRNA transcripts. |
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Comprehensive annotations of eukaryotic long non-coding RNAs. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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A comprehensive, authoritative compendium of human genes and genetic phenotypes. |
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The catalogue of somatic mutations in cancer. |
