Basic Information
Regular Relationship :
Phenotype/DiseaseSpecieAcute Myeloid Leukemia
CeRNA1MEG3[LncRNA]
miRNAmiR-22-5p[miRNA]
CeRNA2TET2[mRNA]
Tissue/Cell lineK562
SpecieHomo sapiens (human)
CitationOncotarget 2017 Sep 12 8, 65211-65217 doi:10.18632/oncotarget.18059 PMID:29029424
Reference title
microRNA-22 can regulate expression of the long non-coding RNA MEG3 in acute myeloid leukemia
Experimental verification
qPCR
Functional description
The lower expression of MEG3 and TET2 in AML cell lines was detected by RT-qPCR.The stable MEG3, TET2 overexpression cell pools in K562 cells was successful established.After transfection, MTT assay revealed that cell growth was significantly increased in AML cell lines transfected with TET2 compared with controls.
Annotations
External Annotation for MEG3 |
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LncRNA-associated competing triplets and functions. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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Infer genomic variations that disturb lncRNA-associated ceRNA regulation.. |
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Provide and annotate disease or phenotype-associated variants in human long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) or their regulatory elements. |
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Providing cellular-specific lncRNA-associated ceRNA networks predicted via high-throughput analysis of single-cell genomic data. |
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Information on all annotated and predicted human genes. |
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Gene nomenclature, gene families and associated resources (genomic, proteomic, phenotypic information). |
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Genome browser for vertebrate genomes. |
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An annotated collection of all publicly available DNA sequences. |
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A wiki-based platform for community curation of human long non-coding RNAs. |
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An integrated knowledge database dedicated to non-coding RNAs. |
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An integrated database of human annotated lncRNA transcripts. |
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Comprehensive annotations of eukaryotic long non-coding RNAs. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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A comprehensive, authoritative compendium of human genes and genetic phenotypes. |
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The catalogue of somatic mutations in cancer. |
