Basic Information
Regular Relationship :
Phenotype/DiseaseSpecieOsteosarcoma
CeRNA1miR210HG[LncRNA]
miRNAmiR-503[miRNA]
CeRNA2vimentin[mRNA]
Tissue/Cell lineU2Os, Saos-2, Hos,Mg-63, And 143B,Nhost,Fob
SpecieHomo sapiens (human)
CitationDNA Cell Biol 2017 Dec 36, 1117-1125 doi:10.1089/dna.2017.3888 PMID:28972855
Reference title
Long Noncoding RNA miR210HG Sponges miR-503 to Facilitate Osteosarcoma Cell Invasion and Metastasis.
Experimental verification
qPCR,Luciferase reporter assay,Western blot
Functional description
miR210HG expression level was significantly upregulated in 55 cases of osteosarcoma tissue samples compared to adjacent normal tissue.the aberrantly enhanced miR210HG expression predicted poor prognosis and lower survival rate.miR210HG knockdown suppressed the osteosarcoma cell proliferation, invasion, and epithelial-mesenchymal transition-related marker(N-cadherin and vimentin) expression.miR210HG silencing decreased the tumor growth. miR-503 was verified to be the target miRNA of miR210HG.miR-503 could reverse the role of miR210HG on osteosarcoma cells.miR210HG sponges miR-503 to facilitate osteosarcoma cell invasion and metastasis,revealing the oncogenic role of miR210HG on osteosarcoma cells.
Annotations
External Annotation for miR210HG |
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LncRNA-associated competing triplets and functions. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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Infer genomic variations that disturb lncRNA-associated ceRNA regulation.. |
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Provide and annotate disease or phenotype-associated variants in human long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) or their regulatory elements. |
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Providing cellular-specific lncRNA-associated ceRNA networks predicted via high-throughput analysis of single-cell genomic data. |
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Information on all annotated and predicted human genes. |
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Gene nomenclature, gene families and associated resources (genomic, proteomic, phenotypic information). |
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Genome browser for vertebrate genomes. |
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An annotated collection of all publicly available DNA sequences. |
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A wiki-based platform for community curation of human long non-coding RNAs. |
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An integrated knowledge database dedicated to non-coding RNAs. |
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An integrated database of human annotated lncRNA transcripts. |
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Comprehensive annotations of eukaryotic long non-coding RNAs. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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A comprehensive, authoritative compendium of human genes and genetic phenotypes. |
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The catalogue of somatic mutations in cancer. |
