Basic Information
Regular Relationship :
Phenotype/DiseaseSpecieHepatocellular Carcinoma
CeRNA1NEAT1[LncRNA]
miRNAmiR-485[miRNA]
CeRNA2STAT3[mRNA]
Tissue/Cell lineHuh7, Hep3B, Hepg2, Bel-7404, Sk-Hep1, Lo2 And Hek-293T
SpecieHomo sapiens (human)
CitationJ Cell Physiol 2018 Sep 233, 6733-6741 doi:10.1002/jcp.26371 PMID:29219178
Reference title
The long noncoding RNA NEAT1 contributes to hepatocellular carcinoma development by sponging miR-485 and enhancing the expression of the STAT3.
Experimental verification
qPCR,Luciferase reporter assay,Western blot,RIP
Functional description
miR-485 was significantly downregulated in HCC cells.miR-485 was increased by sh-NEAT1 and miR-485 can modulate NEAT1 expression negatively. miR-485 was confirmed as a interacting target of NEAT1.STAT3 was recognized as a direct target of miR-485 and miR-485 mimics can inhibit STAT3 expression.NEAT1 can act as a competing endogenous lncRNA (ceRNA) to regulated STAT3 by sponging miR-485 in HCC. Taken these together, NEAT1 can be used as an important biomarker in HCC diagnosis and treatment.STAT3 can regulate various genes which can control proliferation, survival, and invasion process.
Annotations
External Annotation for NEAT1 |
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LncRNA-associated competing triplets and functions. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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Infer genomic variations that disturb lncRNA-associated ceRNA regulation.. |
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Provide and annotate disease or phenotype-associated variants in human long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) or their regulatory elements. |
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Providing cellular-specific lncRNA-associated ceRNA networks predicted via high-throughput analysis of single-cell genomic data. |
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Information on all annotated and predicted human genes. |
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Gene nomenclature, gene families and associated resources (genomic, proteomic, phenotypic information). |
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Genome browser for vertebrate genomes. |
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An annotated collection of all publicly available DNA sequences. |
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A wiki-based platform for community curation of human long non-coding RNAs. |
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An integrated knowledge database dedicated to non-coding RNAs. |
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An integrated database of human annotated lncRNA transcripts. |
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Comprehensive annotations of eukaryotic long non-coding RNAs. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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A comprehensive, authoritative compendium of human genes and genetic phenotypes. |
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The catalogue of somatic mutations in cancer. |
