Basic Information
Regular Relationship :
Phenotype/DiseaseSpecieCardiac Myocytes
CeRNA1lenti-decoy 133[Artifically engineered RNA]
miRNAmiR-133[miRNA]
CeRNA2GLUT4[mRNA]
Tissue/Cell lineCardiac Myocytes
SpecieHomo sapiens (human)
CitationBiochem Biophys Res Commun 2009 Nov 13 389, 315-20 doi:10.1016/j.bbrc.2009.08.136 PMID:19720047
Reference title
MicroRNA-133 regulates the expression of GLUT4 by targeting KLF15 and is involved in metabolic control in cardiac myocytes
Experimental verification
qRT-PCR;luciferase reporter assays
Functional description
Cardiac myocytes infected with lenti-decoy, in which the 3UTR with tandem sequences complementary to miR-133 was linked to the luciferase reporter gene, had decreased miR-133 levels and increased levels of GLUT4. The expression levels of KLF15 and GLUT4 were decreased at the left ventricular hypertrophy and congestive heart failure stage in a rat model. The present results indicated that miR-133 regulates the expression of GLUT4 by targetingKLF15 and is involved in metabolic control in cardiomyocytes.
Annotations
External Annotation for lenti-decoy 133 |
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LncRNA-associated competing triplets and functions. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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Infer genomic variations that disturb lncRNA-associated ceRNA regulation.. |
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Provide and annotate disease or phenotype-associated variants in human long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) or their regulatory elements. |
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Providing cellular-specific lncRNA-associated ceRNA networks predicted via high-throughput analysis of single-cell genomic data. |
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Information on all annotated and predicted human genes. |
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Gene nomenclature, gene families and associated resources (genomic, proteomic, phenotypic information). |
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Genome browser for vertebrate genomes. |
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An annotated collection of all publicly available DNA sequences. |
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A wiki-based platform for community curation of human long non-coding RNAs. |
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An integrated knowledge database dedicated to non-coding RNAs. |
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An integrated database of human annotated lncRNA transcripts. |
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Comprehensive annotations of eukaryotic long non-coding RNAs. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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A comprehensive, authoritative compendium of human genes and genetic phenotypes. |
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The catalogue of somatic mutations in cancer. |
