Basic Information
Regular Relationship :
Phenotype/DiseaseSpecieNon-Small Cell Lung Cancer
CeRNA1NEAT1[LncRNA]
miRNAmiR-377-3p[miRNA]
CeRNA2E2F3[mRNA]
Tissue/Cell lineA549, Spc-A1, H1299, 95D, Sk-Mes-1, Nci-H520
SpecieHomo sapiens (human)
CitationOncol Lett 2017 Oct 14, 4983-4988 doi:10.3892/ol.2017.6769 PMID:29085511
Reference title
Long non-coding RNA NEAT1 regulates E2F3 expression by competitively binding to miR377 in Non small cell lung cancer
Experimental verification
qPCR,Western blot,etc.
Functional description
NEAT1 was highly expressed in NSCLC,and high NEAT1 expression was associated with a shorter overall survival.NEAT1 promoted NSCLC cell growth and affected the cell cycle process in vitro. Furthermore, NEAT1 was observed to bind hsa-miR-377-3p, functioning as a competing endogenous RNA, which resulted in de-repression of its target gene E2F transcription factor 3 (E2F3). E2F3, as an oncogene, may promote NSCLC progression.These results suggested that NEAT1 may promote the development of NSCLC through the miR-377-3p-E2F3 pathway.
Annotations
External Annotation for NEAT1 |
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LncRNA-associated competing triplets and functions. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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Infer genomic variations that disturb lncRNA-associated ceRNA regulation.. |
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Provide and annotate disease or phenotype-associated variants in human long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) or their regulatory elements. |
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Providing cellular-specific lncRNA-associated ceRNA networks predicted via high-throughput analysis of single-cell genomic data. |
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Information on all annotated and predicted human genes. |
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Gene nomenclature, gene families and associated resources (genomic, proteomic, phenotypic information). |
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Genome browser for vertebrate genomes. |
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An annotated collection of all publicly available DNA sequences. |
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A wiki-based platform for community curation of human long non-coding RNAs. |
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An integrated knowledge database dedicated to non-coding RNAs. |
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An integrated database of human annotated lncRNA transcripts. |
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Comprehensive annotations of eukaryotic long non-coding RNAs. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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A comprehensive, authoritative compendium of human genes and genetic phenotypes. |
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The catalogue of somatic mutations in cancer. |
