Basic Information
Regular Relationship :
Phenotype/DiseaseSpecieNasopharyngeal Cancer
CeRNA1NEAT1[LncRNA]
miRNAmiR-101-3p[miRNA]
CeRNA2EMP2[mRNA]
Tissue/Cell line5-8F, Cne1, Cne2, S26, Hne1, Sune1, Hone1, Np69
SpecieHomo sapiens (human)
CitationOncotarget 2017 Sep 19 8, 70156-70171 doi:10.18632/oncotarget.19596 PMID:29050268
Reference title
Long non-coding RNA NEAT1 regulates epithelial membrane protein 2 expression to repress nasopharyngeal carcinoma migration and irradiation-resistance through miR-101-3p as a competing endogenous RNA mechanism.
Experimental verification
qPCR,Western blot etc.
Functional description
NEAT1 is down-regulated in NPC tissues and is associated with poor prognosis. NEAT1 antagonized miR-101-3p through a competing endogenous RNA (ceRNA) mechanism and that the interaction between NEAT1 and EMP2 was miR-101-3p dependent. a novel connection of NEAT1, miR-101-3p and EMP2 in NPC migration and radiation resistance. NPC patients with high NEAT1 expression levels had longer overall survival than patients with low and negative NEAT1 expression levels.
Annotations
External Annotation for NEAT1 |
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LncRNA-associated competing triplets and functions. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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Infer genomic variations that disturb lncRNA-associated ceRNA regulation.. |
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Provide and annotate disease or phenotype-associated variants in human long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) or their regulatory elements. |
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Providing cellular-specific lncRNA-associated ceRNA networks predicted via high-throughput analysis of single-cell genomic data. |
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Information on all annotated and predicted human genes. |
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Gene nomenclature, gene families and associated resources (genomic, proteomic, phenotypic information). |
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Genome browser for vertebrate genomes. |
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An annotated collection of all publicly available DNA sequences. |
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A wiki-based platform for community curation of human long non-coding RNAs. |
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An integrated knowledge database dedicated to non-coding RNAs. |
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An integrated database of human annotated lncRNA transcripts. |
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Comprehensive annotations of eukaryotic long non-coding RNAs. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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A comprehensive, authoritative compendium of human genes and genetic phenotypes. |
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The catalogue of somatic mutations in cancer. |
