Basic Information
Regular Relationship :
Phenotype/DiseaseSpecieColorectal Cancer
CeRNA1PART1[LncRNA]
miRNAmiR-143[miRNA]
CeRNA2DNMT3A[mRNA]
Tissue/Cell lineLovo,Sw620
SpecieHomo sapiens (human)
CitationBiochem Biophys Res Commun 2017 Aug 19 490, 317-323 doi:10.1016/j.bbrc.2017.06.042 PMID:28619512
Reference title
PART-1 functions as a competitive endogenous RNA for promoting tumor progression by sponging miR-143 in colorectal cancer.
Experimental verification
qPCR,Western blot,luciferase reporter assay
Functional description
In the present study, we revealed that prostrate androgen-regulated transcript1 (PART-1) was highly expressed in colorectal cancer cells and tissues , and knockdown of PART-1 suppressed cell proliferation and metastasis, both in vitro and in vivo. In addition, PART-1 functioned as a ceRNA of DNMT3A,by sponging miR-143. Finally,PART-1 induced tumor progression by regulating DNMT3A. The Kaplan-Meier log-rank test was used to compare survival curves.Several studies have reported that miR-143 could regulate tumor progression through direct interaction with DNMT3A. As an enzyme modulating DNA methylation, DNMT3A can exert diverse epigenetic regulations.
Annotations
External Annotation for PART1 |
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LncRNA-associated competing triplets and functions. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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Infer genomic variations that disturb lncRNA-associated ceRNA regulation.. |
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Provide and annotate disease or phenotype-associated variants in human long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) or their regulatory elements. |
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Providing cellular-specific lncRNA-associated ceRNA networks predicted via high-throughput analysis of single-cell genomic data. |
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Information on all annotated and predicted human genes. |
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Gene nomenclature, gene families and associated resources (genomic, proteomic, phenotypic information). |
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Genome browser for vertebrate genomes. |
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An annotated collection of all publicly available DNA sequences. |
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A wiki-based platform for community curation of human long non-coding RNAs. |
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An integrated knowledge database dedicated to non-coding RNAs. |
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An integrated database of human annotated lncRNA transcripts. |
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Comprehensive annotations of eukaryotic long non-coding RNAs. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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A comprehensive, authoritative compendium of human genes and genetic phenotypes. |
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The catalogue of somatic mutations in cancer. |
