Basic Information
Regular Relationship :
Phenotype/DiseaseSpecieNasopharyngeal Cancer
CeRNA1PCAT7[LncRNA]
miRNAmiR-134-5p[miRNA]
CeRNA2ELF2[mRNA]
Tissue/Cell lineSune-1, Cne-1, Hne-1, Cne2, C666-1, Hone-1.Nasopharyngeal Carcinoma Tissues
SpecieHomo sapiens (human)
CitationBiochem Biophys Res Commun 2017 Sep 16 491, 374-381 doi:10.1016/j.bbrc.2017.07.093 PMID:28728844
Reference title
Long non-coding RNA PCAT7 regulates ELF2 signaling through inhibition of miR-134-5p in nasopharyngeal carcinoma.
Experimental verification
qPCR,Western blot,Luciferase reporter assay,RNAi,etc.
Functional description
Decreased PCAT7 expression was found to significantly suppress tumor cell proliferation in vitro, and inhibited tumor growth and reduced the expression of proliferation antigen Ki67 in vivo. Rescue assay was performed to further confirm that PCAT7 contributed to the progression of NPC through regulating miR-134-5p/ELF2 signal pathway.The Kaplan-Meier survival analysis indicated that PCAT7 high expression has a worse overall survival compared to the low expression subgroup. These results indicated that PCAT7 might contribute to the tumor progression in NPC by functioning as a ceRNA to sponge miR-134-5p.To explore the interaction between PCAT7 and targeted miRNA, we predicted the miRNAs that might interact with PCAT7 using miRDB.
Annotations
External Annotation for PCAT7 |
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LncRNA-associated competing triplets and functions. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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Infer genomic variations that disturb lncRNA-associated ceRNA regulation.. |
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Provide and annotate disease or phenotype-associated variants in human long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) or their regulatory elements. |
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Providing cellular-specific lncRNA-associated ceRNA networks predicted via high-throughput analysis of single-cell genomic data. |
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Information on all annotated and predicted human genes. |
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Gene nomenclature, gene families and associated resources (genomic, proteomic, phenotypic information). |
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Genome browser for vertebrate genomes. |
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An annotated collection of all publicly available DNA sequences. |
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A wiki-based platform for community curation of human long non-coding RNAs. |
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An integrated knowledge database dedicated to non-coding RNAs. |
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An integrated database of human annotated lncRNA transcripts. |
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Comprehensive annotations of eukaryotic long non-coding RNAs. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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A comprehensive, authoritative compendium of human genes and genetic phenotypes. |
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The catalogue of somatic mutations in cancer. |
