Basic Information
Regular Relationship :
Phenotype/DiseaseSpecieOral Squamous Cell Cancer
CeRNA1PDIA3P[LncRNA]
miRNAmiR-185-5p[miRNA]
CeRNA2CCND2[mRNA]
Tissue/Cell lineScc4, Scc9, Scc1, Scc25, Tu183, Hsu3,Fadu, Oec-M1, Snu1041,Scc15 And The Nhok
SpecieHomo sapiens (human)
CitationMol Ther Nucleic Acids 2017 Dec 15 9, 100-110 doi:10.1016/j.omtn.2017.08.015 PMID:29246288
Reference title
The lncRNA PDIA3P Interacts with miR-185-5p to Modulate Oral Squamous Cell Carcinoma Progression by Targeting Cyclin D2.
Experimental verification
qPCR,Luciferase reporter assay,RNAi
Functional description
PDIA3P was overexpressed in oral squamous cell carcinoma (OSCC) and decreased the survival rate of OSCC patients.silencing PDIA3P by small interfering RNA (siRNA) inhibited OSCC cell proliferation and repressed tumor growth and reduced the expression of proliferation antigen Ki-67 invivo. PDIA3P negatively regulated miR-185-5p in OSCC cells.silencing PDIA3P by siRNA suppressed proliferation via miR-185-5p in OSCC cells.silencing PDIA3P by siRNA inhibited CCND2 protein (no influence on mRNA levels) expression via miR-185-5p in OSCC cells, and CCND2 facilitated cell proliferation of SCC4 and SCC15 cells induced by sh-PDIA3P1.
Annotations
External Annotation for PDIA3P |
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LncRNA-associated competing triplets and functions. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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Infer genomic variations that disturb lncRNA-associated ceRNA regulation.. |
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Provide and annotate disease or phenotype-associated variants in human long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) or their regulatory elements. |
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Providing cellular-specific lncRNA-associated ceRNA networks predicted via high-throughput analysis of single-cell genomic data. |
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Information on all annotated and predicted human genes. |
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Gene nomenclature, gene families and associated resources (genomic, proteomic, phenotypic information). |
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Genome browser for vertebrate genomes. |
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An annotated collection of all publicly available DNA sequences. |
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A wiki-based platform for community curation of human long non-coding RNAs. |
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An integrated knowledge database dedicated to non-coding RNAs. |
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An integrated database of human annotated lncRNA transcripts. |
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Comprehensive annotations of eukaryotic long non-coding RNAs. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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A comprehensive, authoritative compendium of human genes and genetic phenotypes. |
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The catalogue of somatic mutations in cancer. |
