Basic Information
Regular Relationship :
Phenotype/DiseaseSpecieNon-Small Cell Lung Cancer
CeRNA1PVT1[LncRNA]
miRNAmiR-199a-5p[miRNA]
CeRNA2HIF1a[mRNA]
Tissue/Cell lineA549 And Spca-1
SpecieHomo sapiens (human)
CitationMol Med Rep 2018 Jan 17, 1105-1110 doi:10.3892/mmr.2017.7962 PMID:29115513
Reference title
LncRNA PVT1 regulate expression of HIF1α via functioning as ceRNA for miR-199a-5p in Non small cell lung cancer under hypoxia.
Experimental verification
qPCR,Western blot
Functional description
PVT1 was overexpressed in the hypoxic lung cancer cells.PVT1 functioned as competing endogenous (ceRNA) for miR199a5p, upregulated expression of its endogenous targets HIF1α and inhibited its function.
Annotations
External Annotation for PVT1 |
|
|---|---|
 |
LncRNA-associated competing triplets and functions. |
 |
Comprehensive experimentally supported associations between lncRNA and human cancer. |
 |
Infer genomic variations that disturb lncRNA-associated ceRNA regulation.. |
 |
Provide and annotate disease or phenotype-associated variants in human long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) or their regulatory elements. |
 |
Providing cellular-specific lncRNA-associated ceRNA networks predicted via high-throughput analysis of single-cell genomic data. |
 |
Information on all annotated and predicted human genes. |
 |
Gene nomenclature, gene families and associated resources (genomic, proteomic, phenotypic information). |
 |
Genome browser for vertebrate genomes. |
 |
An annotated collection of all publicly available DNA sequences. |
 |
A wiki-based platform for community curation of human long non-coding RNAs. |
 |
An integrated knowledge database dedicated to non-coding RNAs. |
 |
An integrated database of human annotated lncRNA transcripts. |
 |
Comprehensive annotations of eukaryotic long non-coding RNAs. |
 |
Comprehensive experimentally supported associations between lncRNA and human cancer. |
 |
A comprehensive, authoritative compendium of human genes and genetic phenotypes. |
 |
The catalogue of somatic mutations in cancer. |
