Basic Information
Regular Relationship :
Phenotype/DiseaseSpeciePapillary Thyroid Cancer
CeRNA1lincRNA-ROR[LncRNA]
miRNAmiR-145[miRNA]
CeRNA2TGFB[mRNA]
Tissue/Cell lineTpc1, Ffpe Tissue
SpecieHomo sapiens (human)
CitationEndocr Pathol 2018 Mar 29, 1-8 doi:10.1007/s12022-017-9507-2 PMID:29280051
Reference title
Long Non-coding RNA Linc-ROR Is Upregulated in Papillary Thyroid Carcinoma.
Experimental verification
qPCR,in vitro knockdown wtc
Functional description
ROR was shown to exert regulatory effect in proliferation, invasion, and stemness of gastricc arcinoma stem cells and in breast cancer,pancreatic cancer, hepatocellular cancer, endometrial cancer, and naso- pharyngeal carcinomas.ROR lncRNA had a negative regulatory on miR-145.SiRNA experiments with ROR also led to increased expression of miR-145, supporting the role of ROR as an endogenous miR-145 sponge.There was upregulation of miR-145 after ROR silencing with a specific siRNA.
Annotations
External Annotation for lincRNA-ROR |
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LncRNA-associated competing triplets and functions. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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Infer genomic variations that disturb lncRNA-associated ceRNA regulation.. |
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Provide and annotate disease or phenotype-associated variants in human long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) or their regulatory elements. |
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Providing cellular-specific lncRNA-associated ceRNA networks predicted via high-throughput analysis of single-cell genomic data. |
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Information on all annotated and predicted human genes. |
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Gene nomenclature, gene families and associated resources (genomic, proteomic, phenotypic information). |
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Genome browser for vertebrate genomes. |
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An annotated collection of all publicly available DNA sequences. |
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A wiki-based platform for community curation of human long non-coding RNAs. |
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An integrated knowledge database dedicated to non-coding RNAs. |
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An integrated database of human annotated lncRNA transcripts. |
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Comprehensive annotations of eukaryotic long non-coding RNAs. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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A comprehensive, authoritative compendium of human genes and genetic phenotypes. |
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The catalogue of somatic mutations in cancer. |
