Basic Information
Regular Relationship :
Phenotype/DiseaseSpecieRenal Cancer
CeRNA1RP11-436H11.5[LncRNA]
miRNAmiR-335-5p[miRNA]
CeRNA2BCL-W[mRNA]
Tissue/Cell lineA498, 786-O, Osrc-2
SpecieHomo sapiens (human)
CitationMol Cancer 2017 Oct 25 16, 166 doi:10.1186/s12943-017-0735-3 PMID:29070041
Reference title
LncRNA RP11-436H11.5, functioning as a competitive endogenous RNA, upregulates BCL-W expression by sponging miR-335-5p and promotes proliferation and invasion in renal cell carcinoma
Experimental verification
qPCR,Luciferase reporter assay,Western blot etc.
Functional description
The results of survival analysis indicated that patients in the high lncRNA RP11-436H11.5 group presented significantly worse outcomes compared with those in the low lncRNA RP11-436H11.5 group. Downregulation of lncRNA RP11-436H11.5 suppressed RCC cell proliferation and invasion in vitro and in vivo. Luciferase reporter assay results demonstrated that lncRNA RP11-436H11.5 enhanced BCL-W expression by regulating miR-335-5p expression. LncRNA RP11-436H11.5 could function as a miR-335-5p decoy to derepress expression of BCL-W. LncRNA RP11-436H11.5 could function as a competing endogenous RNA to promote RCC cell proliferation and invasion, which might serve as a therapeutic application to suppress RCC progression.lncRNA RP11-436H11.5 can function as a miR-335-5p decoy to derepress BCL-W and promote RCC cell proliferation and invasion. An orthotopic xenograft mouse model indicated that lncRNA RP11-436H11.5 could participate in miR-335-BCL-W-mediated RCC cell proliferation and invasion. LncRNA RP11-436H11.5 may be a novel therapeutic target and prognostic marker in RCC.
Annotations
External Annotation for RP11-436H11.5 |
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LncRNA-associated competing triplets and functions. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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Infer genomic variations that disturb lncRNA-associated ceRNA regulation.. |
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Provide and annotate disease or phenotype-associated variants in human long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) or their regulatory elements. |
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Providing cellular-specific lncRNA-associated ceRNA networks predicted via high-throughput analysis of single-cell genomic data. |
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Information on all annotated and predicted human genes. |
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Gene nomenclature, gene families and associated resources (genomic, proteomic, phenotypic information). |
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Genome browser for vertebrate genomes. |
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An annotated collection of all publicly available DNA sequences. |
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A wiki-based platform for community curation of human long non-coding RNAs. |
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An integrated knowledge database dedicated to non-coding RNAs. |
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An integrated database of human annotated lncRNA transcripts. |
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Comprehensive annotations of eukaryotic long non-coding RNAs. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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A comprehensive, authoritative compendium of human genes and genetic phenotypes. |
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The catalogue of somatic mutations in cancer. |
