Basic Information
Regular Relationship :
Phenotype/DiseaseSpecieColorectal Cancer
CeRNA1SNHG1[LncRNA]
miRNAmiR-145[miRNA]
CeRNA2p70S6k[mRNA]
Tissue/Cell lineLovo And Hct116
SpecieHomo sapiens (human)
CitationOncotarget 2018 Jan 5 9, 2128-2139 doi:10.18632/oncotarget.23255 PMID:29416759
Reference title
SNHG1 promotes cell proliferation by acting as a sponge of miR-145 in colorectal cancer.
Experimental verification
qPCR,Western blot
Functional description
SNHG1 expression was correlated with advanced colorectal cancer stage and tumor recurrence.SNHG1 promoted cell proliferation by acting as a sponge of miR-145, a well known tumor suppressor of colorectal cancer.colorectal cancer patients with higher expression of SNHG1 had a worse prognosis.SNHG1 may act as a potential therapeutic target for the treatment of colorectal cancer.
Annotations
External Annotation for SNHG1 |
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LncRNA-associated competing triplets and functions. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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Infer genomic variations that disturb lncRNA-associated ceRNA regulation.. |
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Provide and annotate disease or phenotype-associated variants in human long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) or their regulatory elements. |
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Providing cellular-specific lncRNA-associated ceRNA networks predicted via high-throughput analysis of single-cell genomic data. |
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Information on all annotated and predicted human genes. |
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Gene nomenclature, gene families and associated resources (genomic, proteomic, phenotypic information). |
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Genome browser for vertebrate genomes. |
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An annotated collection of all publicly available DNA sequences. |
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A wiki-based platform for community curation of human long non-coding RNAs. |
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An integrated knowledge database dedicated to non-coding RNAs. |
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An integrated database of human annotated lncRNA transcripts. |
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Comprehensive annotations of eukaryotic long non-coding RNAs. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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A comprehensive, authoritative compendium of human genes and genetic phenotypes. |
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The catalogue of somatic mutations in cancer. |
