Basic Information
Regular Relationship :
Tissue/Cell lineU251 And U87
SpecieHomo sapiens (human)
CitationBiomed Pharmacother 2017 Jul 91, 906-911 doi:10.1016/j.biopha.2017.05.014 PMID:28501778
Reference title
Upregulation of the long non-coding RNA SNHG1 predicts poor prognosis, promotes cell proliferation and invasion, and reduces apoptosis in glioma.
Experimental verification
qPCR etc.
Functional description
SNHG1 expression was measured in glioma tissues and cell lines.The association between SNHG1 expression in tissues and clinicopathological characteristics and prognosis in glioma patients was also explored. SNHG1 was highly expressed in glioma tissues, and its upregulation was closely related to old age.ectopic expression of SNHG1 enhanced cell proliferation and cell invasion and reduced cell apoptosis in vitro, while SNHG1 knockdown reversed these effects. Taken together, our findings indicate that SNHG1 functions as an oncogene in glioma and may serve as a novel therapeutic target in future treatments.High expression of SNHG1 correlates with large tumor size, poor differentiation,aggressive BCLC stage and poor prognosis of HCC patients.High expression of SNHG1 also exacerbates HCC cell proliferation, invasion, and migration in vitro via suppression of miR-195 and p53.SNHG1 promoted cell proliferation via proto-oncogene CST3 upregulation by acting as a non-degradable sponge for the tumor suppressor miR-338 in esophageal cancer cells.
Annotations
External Annotation for SNHG1 |
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LncRNA-associated competing triplets and functions. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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Infer genomic variations that disturb lncRNA-associated ceRNA regulation.. |
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Provide and annotate disease or phenotype-associated variants in human long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) or their regulatory elements. |
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Providing cellular-specific lncRNA-associated ceRNA networks predicted via high-throughput analysis of single-cell genomic data. |
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Information on all annotated and predicted human genes. |
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Gene nomenclature, gene families and associated resources (genomic, proteomic, phenotypic information). |
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Genome browser for vertebrate genomes. |
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An annotated collection of all publicly available DNA sequences. |
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A wiki-based platform for community curation of human long non-coding RNAs. |
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An integrated knowledge database dedicated to non-coding RNAs. |
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An integrated database of human annotated lncRNA transcripts. |
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Comprehensive annotations of eukaryotic long non-coding RNAs. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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A comprehensive, authoritative compendium of human genes and genetic phenotypes. |
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The catalogue of somatic mutations in cancer. |
