Basic Information
Regular Relationship :
Tissue/Cell lineSgc7901, Nci-N87 And Ags And Normal Gastric Epithelial Cell Line
SpecieHomo sapiens (human)
CitationMol Med Rep 2018 Feb 17, 2743-2749 doi:10.3892/mmr.2017.8143 PMID:29207106
Reference title
LncRNA SNHG12 regulates gastric cancer progression by acting as a molecular sponge of miR320.
Experimental verification
RT-qPCR,Western blot,Luciferase reporter assay,in vitro knockdown
Functional description
SNHG12 was significantly overexpressed in GC and its expression level was highly associated with tumor size, tumornodemetastasis stage, distant metastasis, lymphatic metastasis.Additionally, inhibition of SNHG12 in GC cell lines SGC7901 and AGS suppressed cell growth, colony formation, proliferation and invasion. MicroRNA (miR)320,a putative target gene of SNHG12, was inversely correlated with SNHG12 expression in GC tissues and cell lines. In addition,the present study determined that miR320 was directly regulated by SNHG12 and suppression of miR320 expression reversed the inhibitory effects of SNHG12 siRNA on GC cell proliferation and invasion.
Annotations
External Annotation for SNHG12 |
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LncRNA-associated competing triplets and functions. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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Infer genomic variations that disturb lncRNA-associated ceRNA regulation.. |
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Provide and annotate disease or phenotype-associated variants in human long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) or their regulatory elements. |
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Providing cellular-specific lncRNA-associated ceRNA networks predicted via high-throughput analysis of single-cell genomic data. |
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Information on all annotated and predicted human genes. |
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Gene nomenclature, gene families and associated resources (genomic, proteomic, phenotypic information). |
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Genome browser for vertebrate genomes. |
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An annotated collection of all publicly available DNA sequences. |
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A wiki-based platform for community curation of human long non-coding RNAs. |
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An integrated knowledge database dedicated to non-coding RNAs. |
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An integrated database of human annotated lncRNA transcripts. |
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Comprehensive annotations of eukaryotic long non-coding RNAs. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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A comprehensive, authoritative compendium of human genes and genetic phenotypes. |
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The catalogue of somatic mutations in cancer. |
