Basic Information
Regular Relationship :
Phenotype/DiseaseSpecieClear Cell Renal Cancer
CeRNA1SNHG14[LncRNA]
miRNAmiR-203[miRNA]
CeRNA2N-WASP[mRNA]
Tissue/Cell lineA-498, 786-O,Caki-2, Caki-1,Hk-2
SpecieHomo sapiens (human)
CitationAm J Cancer Res 2017 7, 2515-2525, PMID:29312804
Reference title
SP1-induced up-regulation of lncRNA SNHG14 as a ceRNA promotes migration and invasion of clear cell renal cell carcinoma by regulating N-WASP.
Experimental verification
qPCR,Luciferase reporter assay,Western blot,RIP
Functional description
SNHG14 was significantly up-regulated in ccRCC cell lines.the transcription factor SP1 can bind to the promoter region of SNHG14, resulting in the overexpression of SNHG14 in ccRCC. enhanced expression of lncRNA SNHG14 promoted cell migration and invasion through promoting N-WASP protein level. SNHG14 functioned as ceRNA to regulate N-WASP expression and cell motility ability via a miR-203-dependent manner.SNHG14 is a critical lncRNA that promotes ccRCC migration and invasion via sponging miR-203 and elevating N-WASP.
Annotations
External Annotation for SNHG14 |
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LncRNA-associated competing triplets and functions. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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Infer genomic variations that disturb lncRNA-associated ceRNA regulation.. |
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Provide and annotate disease or phenotype-associated variants in human long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) or their regulatory elements. |
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Providing cellular-specific lncRNA-associated ceRNA networks predicted via high-throughput analysis of single-cell genomic data. |
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Information on all annotated and predicted human genes. |
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Gene nomenclature, gene families and associated resources (genomic, proteomic, phenotypic information). |
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Genome browser for vertebrate genomes. |
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An annotated collection of all publicly available DNA sequences. |
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A wiki-based platform for community curation of human long non-coding RNAs. |
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An integrated knowledge database dedicated to non-coding RNAs. |
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An integrated database of human annotated lncRNA transcripts. |
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Comprehensive annotations of eukaryotic long non-coding RNAs. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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A comprehensive, authoritative compendium of human genes and genetic phenotypes. |
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The catalogue of somatic mutations in cancer. |
