Basic Information
Regular Relationship :
Phenotype/DiseaseSpecieColorectal Cancer
CeRNA1SNHG3[LncRNA]
miRNAmiR-182-5p[miRNA]
CeRNA2c-Myc[mRNA]
Tissue/Cell lineHt29, Hct116, Sw480, Lovo
SpecieHomo sapiens (human)
CitationOncol Rep 2017 Sep 38, 1402-1410 doi:10.3892/or.2017.5837 PMID:28731158
Reference title
The long non-coding RNA SNHG3 functions as a competing endogenous RNA to promote malignant development of colorectal cancer.
Experimental verification
qPCR,Luciferase reporter assay,RIP,Western blot
Functional description
SNHG3 promoted CRC progression via sponging miR-182-5p and upregulating c-Myc and its target genes.The results confirmed that SNHG3 was markedly upregulated in CRC.Notably, Kaplan-Meier analysis and log-rank test demonstrated that patients with overexpression of SNHG3 had poorer overall survival time than those with low expression of SNHG3.HOTAIR expression levels were significantly positively correlated with hepatocellular carcinoma (HCC) recurrence and metastasis and with the overall survival time of patients with HCC.
Annotations
External Annotation for SNHG3 |
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LncRNA-associated competing triplets and functions. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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Infer genomic variations that disturb lncRNA-associated ceRNA regulation.. |
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Provide and annotate disease or phenotype-associated variants in human long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) or their regulatory elements. |
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Providing cellular-specific lncRNA-associated ceRNA networks predicted via high-throughput analysis of single-cell genomic data. |
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Information on all annotated and predicted human genes. |
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Gene nomenclature, gene families and associated resources (genomic, proteomic, phenotypic information). |
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Genome browser for vertebrate genomes. |
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An annotated collection of all publicly available DNA sequences. |
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A wiki-based platform for community curation of human long non-coding RNAs. |
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An integrated knowledge database dedicated to non-coding RNAs. |
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An integrated database of human annotated lncRNA transcripts. |
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Comprehensive annotations of eukaryotic long non-coding RNAs. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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A comprehensive, authoritative compendium of human genes and genetic phenotypes. |
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The catalogue of somatic mutations in cancer. |
