Basic Information
Regular Relationship :
Tissue/Cell lineAtc, Sw1736, Kat18, Ftc, Ftc133, Hgc-27
SpecieHomo sapiens (human)
CitationActa Biochim Biophys Sin (Shanghai) 2017 Jul 1 49, 588-597 doi:10.1093/abbs/gmx047 PMID:28645161
Reference title
LncRNA TUG1 influences papillary thyroid cancer cell proliferation, migration and EMT formation through targeting miR-145.
Experimental verification
qPCR,Western blot etc.
Functional description
TUG1 contributes to the progression of thyroid cancer cells through regulating miR-145/ZEB1 signal pathway.LncRNA TUG1 was found to be up-regulated in thyroid cancer tissues and thyroid cancer cells compared with that in the human normal breast epithelial cell HGC-27.Increased lncRNA TUG1 expression was found to significantly promote tumor cell proliferation,and facilitate cell invasion,while down-regulated TUG1 could obviously inhibit cell proliferation,migration/invasion and reverse EMT to MET.These results indicated that TUG1 may contribute to the progression of thyroid cancer cells by function as a ceRNA competitive sponging miR-145,and that lncRNA TUG1 is associated with tumor progression in thyroid cancer cells.
Annotations
External Annotation for TUG1 |
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LncRNA-associated competing triplets and functions. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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Infer genomic variations that disturb lncRNA-associated ceRNA regulation.. |
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Provide and annotate disease or phenotype-associated variants in human long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) or their regulatory elements. |
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Providing cellular-specific lncRNA-associated ceRNA networks predicted via high-throughput analysis of single-cell genomic data. |
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Information on all annotated and predicted human genes. |
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Gene nomenclature, gene families and associated resources (genomic, proteomic, phenotypic information). |
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Genome browser for vertebrate genomes. |
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An annotated collection of all publicly available DNA sequences. |
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A wiki-based platform for community curation of human long non-coding RNAs. |
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An integrated knowledge database dedicated to non-coding RNAs. |
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An integrated database of human annotated lncRNA transcripts. |
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Comprehensive annotations of eukaryotic long non-coding RNAs. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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A comprehensive, authoritative compendium of human genes and genetic phenotypes. |
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The catalogue of somatic mutations in cancer. |
