Basic Information
Regular Relationship :
Tissue/Cell lineSw1990，Bxpc-3, Miapaca-2, Panc-1, Capan-1
SpecieHomo sapiens (human)
CitationOncol Res 2017 Nov 2 25, 1529-1541 doi:10.3727/096504017x14888987683152 PMID:28315290
Reference title
UCA1 Regulates the Growth and Metastasis of Pancreatic Cancer By Sponging MiR-135a.
Experimental verification
qPCR,RNAi,Northern blot,Luciferase reporter assay,Flow cytometry assay etc.
Functional description
UCA1 was overexpressed in PC tissues and cell lines. The proliferation of PC cells was inhibited after UCA1 was suppressed by a lentiviral vector. Cell apoptosis rate was largely promoted by down-regulating UCA1. Luciferase activity assay further comfirmed the targeting relationship between UCA1 and miR-135a. Moreover, miRNA-135a reversed the effect of UCA1 on cell apoptosis rate and cell viability in SW1990 cells. The migration and invasion capacity of PC cells suppressed by UCA1 siRNA was then enhanced by miR-135a inhibitor.
Annotations
External Annotation for UCA1 |
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LncRNA-associated competing triplets and functions. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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Infer genomic variations that disturb lncRNA-associated ceRNA regulation.. |
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Provide and annotate disease or phenotype-associated variants in human long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) or their regulatory elements. |
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Providing cellular-specific lncRNA-associated ceRNA networks predicted via high-throughput analysis of single-cell genomic data. |
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Information on all annotated and predicted human genes. |
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Gene nomenclature, gene families and associated resources (genomic, proteomic, phenotypic information). |
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Genome browser for vertebrate genomes. |
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An annotated collection of all publicly available DNA sequences. |
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A wiki-based platform for community curation of human long non-coding RNAs. |
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An integrated knowledge database dedicated to non-coding RNAs. |
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An integrated database of human annotated lncRNA transcripts. |
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Comprehensive annotations of eukaryotic long non-coding RNAs. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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A comprehensive, authoritative compendium of human genes and genetic phenotypes. |
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The catalogue of somatic mutations in cancer. |
