Basic Information
Regular Relationship :
Tissue/Cell lineWi-38, Hel-1
SpecieHomo sapiens (human)
CitationOncol Res 2018 May 7 26, 537-546 doi:10.3727/096504017x15009792179602 PMID:28762326
Reference title
Long Noncoding RNA Urothelial Carcinoma Associated 1 Promotes the Proliferation and Metastasis of Human Lung Tumor Cells by Regulating MicroRNA-144
Experimental verification
luciferase reporter assay,qPCR,western blot etc.
Functional description
This result indicated that the up-regulated expression of lncRNA UCA1 was involved in the canceration of normal lung cells. These findings will be helpful for understanding the critical roles of lncRNA UCA1 and miRNA-144 in lung cancer cells, and provide new therapeutic strategy for lung cancer therapy.The experimental study from Cheng et al. demonstrated that lncRNA UCA1 promoted non-T790M cells acquired resistance to epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) by activating the AKT/mammalian target of rapamycin (mTOR) pathway in EGFR-mutant NSCLC.
Annotations
External Annotation for UCA1 |
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LncRNA-associated competing triplets and functions. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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Infer genomic variations that disturb lncRNA-associated ceRNA regulation.. |
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Provide and annotate disease or phenotype-associated variants in human long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) or their regulatory elements. |
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Providing cellular-specific lncRNA-associated ceRNA networks predicted via high-throughput analysis of single-cell genomic data. |
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Information on all annotated and predicted human genes. |
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Gene nomenclature, gene families and associated resources (genomic, proteomic, phenotypic information). |
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Genome browser for vertebrate genomes. |
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An annotated collection of all publicly available DNA sequences. |
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A wiki-based platform for community curation of human long non-coding RNAs. |
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An integrated knowledge database dedicated to non-coding RNAs. |
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An integrated database of human annotated lncRNA transcripts. |
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Comprehensive annotations of eukaryotic long non-coding RNAs. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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A comprehensive, authoritative compendium of human genes and genetic phenotypes. |
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The catalogue of somatic mutations in cancer. |
