Basic Information
Regular Relationship :
Phenotype/DiseaseSpeciePancreatic Cancer
CeRNA1XIST[LncRNA]
miRNAmiR-124[miRNA]
CeRNA2iASPP[mRNA]
Tissue/Cell lineAspc-1, Bxpc3, Sw1990,Panc-1, Capan-1, Capan-2
SpecieHomo sapiens (human)
CitationOncotarget 2017 Dec 26 8, 113701-113718 doi:10.18632/oncotarget.22555 PMID:29371940
Reference title
The lncRNA XIST interacts with miR-140/miR-124/iASPP axisto promote pancreatic carcinoma growth
Experimental verification
qPCR,Western blot,Luciferase reporter assay etc.
Functional description
XIST might be an oncogenic lncRNA that promoted proliferation of PC cell line through inhibiting miR- 140/miR-124 expression and promoting cell cycle-related factor expression, and could be regarded as a therapeutic target in human pancreatic carcinoma.XIST is highly expressed in PC tissues and cell line and related with clinicopathologic features.
Annotations
External Annotation for XIST |
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LncRNA-associated competing triplets and functions. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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Infer genomic variations that disturb lncRNA-associated ceRNA regulation.. |
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Provide and annotate disease or phenotype-associated variants in human long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) or their regulatory elements. |
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Providing cellular-specific lncRNA-associated ceRNA networks predicted via high-throughput analysis of single-cell genomic data. |
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Information on all annotated and predicted human genes. |
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Gene nomenclature, gene families and associated resources (genomic, proteomic, phenotypic information). |
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Genome browser for vertebrate genomes. |
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An annotated collection of all publicly available DNA sequences. |
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A wiki-based platform for community curation of human long non-coding RNAs. |
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An integrated knowledge database dedicated to non-coding RNAs. |
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An integrated database of human annotated lncRNA transcripts. |
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Comprehensive annotations of eukaryotic long non-coding RNAs. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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A comprehensive, authoritative compendium of human genes and genetic phenotypes. |
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The catalogue of somatic mutations in cancer. |
