Basic Information
Regular Relationship :
Phenotype/DiseaseSpecieColorectal Cancer
CeRNA1XIST[LncRNA]
miRNAmiR-132-3p[miRNA]
CeRNA2MAPK1[mRNA]
Tissue/Cell lineLovo, Hct116, Sw620, Sw480 And Ht29
SpecieHomo sapiens (human)
CitationJ buon 2017 May-Jun 22, 696-703, PMID:28730777
Reference title
Long non-coding RNA XIST functions as an oncogene in human colorectal cancer by targeting miR-132-3p
Experimental verification
qPCR,Western blot etc.
Functional description
The expression level of XIST was significantly increased in both CRC tissues sample and CRC cells.XIST promoted CRC cell proliferation by affecting the cell cycle.In addition,XIST and miR-132-3p were inhibited by each other reciprocally.
Annotations
External Annotation for XIST |
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LncRNA-associated competing triplets and functions. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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Infer genomic variations that disturb lncRNA-associated ceRNA regulation.. |
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Provide and annotate disease or phenotype-associated variants in human long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) or their regulatory elements. |
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Providing cellular-specific lncRNA-associated ceRNA networks predicted via high-throughput analysis of single-cell genomic data. |
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Information on all annotated and predicted human genes. |
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Gene nomenclature, gene families and associated resources (genomic, proteomic, phenotypic information). |
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Genome browser for vertebrate genomes. |
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An annotated collection of all publicly available DNA sequences. |
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A wiki-based platform for community curation of human long non-coding RNAs. |
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An integrated knowledge database dedicated to non-coding RNAs. |
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An integrated database of human annotated lncRNA transcripts. |
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Comprehensive annotations of eukaryotic long non-coding RNAs. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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A comprehensive, authoritative compendium of human genes and genetic phenotypes. |
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The catalogue of somatic mutations in cancer. |
