Detail (Experimental CeRNA)

Home Detail(Experimental CeRNA)

Basic Information

Regular Relationship :


Phenotype/DiseaseSpecie

Osteosarcoma

CeRNA1

XIST[LncRNA]

miRNA

miR-320b[miRNA]

CeRNA2

RAP2B[mRNA]


Tissue/Cell line

U2Os, Saos-2, Mg63, And Mnng/Hos

Specie

Homo sapiens (human)

Citation

Oncol Res 2018 Jul 5 26, 837-846 doi:10.3727/096504017x14920318811721 PMID:28409547


Reference title
Long Non-Coding RNA XIST Promotes Osteosarcoma Progression by Targeting Ras-Related Protein RAP2B via miR-320b
Experimental verification
qPCR,Western blot,Luciferase Reporter Assays

Functional description
XIST expression was significantly increased in osteosarcoma tissues and cell lines by LncRNA Profiler and qRT-PCR.The competing relationship between XIST and miR-320b was confirmed by Luciferase report assay.

Annotations

External Annotation for XIST
LncRNA-associated competing triplets and functions.
Comprehensive experimentally supported associations between lncRNA and human cancer.
Infer genomic variations that disturb lncRNA-associated ceRNA regulation..
Provide and annotate disease or phenotype-associated variants in human long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) or their regulatory elements.
Providing cellular-specific lncRNA-associated ceRNA networks predicted via high-throughput analysis of single-cell genomic data.
Information on all annotated and predicted human genes.
Gene nomenclature, gene families and associated resources (genomic, proteomic, phenotypic information).
Genome browser for vertebrate genomes.
An annotated collection of all publicly available DNA sequences.
A wiki-based platform for community curation of human long non-coding RNAs.
An integrated knowledge database dedicated to non-coding RNAs.
An integrated database of human annotated lncRNA transcripts.
Comprehensive annotations of eukaryotic long non-coding RNAs.
Comprehensive experimentally supported associations between lncRNA and human cancer.
A comprehensive, authoritative compendium of human genes and genetic phenotypes.
The catalogue of somatic mutations in cancer.

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