Basic Information
Regular Relationship :
Phenotype/DiseaseSpecieChronic Lymphocytic Leukemia
CeRNA1DLEU2[LncRNA]
miRNAmiR-15a[miRNA]
CeRNA2BCL-2[mRNA]
Tissue/Cell lineChronic lymphocytic leukemia cells
SpecieHomo sapiens (human)
CitationLeuk Lymphoma 2009 Mar 50, 502-5 doi:10.1080/10428190902763509 PMID:19347735
Reference title
Chronic lymphocytic leukemia and 13q14: miRs and more.
Experimental verification
qPCR etc.
Functional description
We propose a model of a multigenic pathomechanism in 13q14.3, where several tumor suppressor genes, including the miRNA genes miR-16-1 and miR-15a, are co-regulated by the two long non-coding RNA genes DLEU1 and DLEU2 that span the critical region.
Annotations
External Annotation for DLEU2 |
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LncRNA-associated competing triplets and functions. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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Infer genomic variations that disturb lncRNA-associated ceRNA regulation.. |
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Provide and annotate disease or phenotype-associated variants in human long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) or their regulatory elements. |
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Providing cellular-specific lncRNA-associated ceRNA networks predicted via high-throughput analysis of single-cell genomic data. |
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Information on all annotated and predicted human genes. |
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Gene nomenclature, gene families and associated resources (genomic, proteomic, phenotypic information). |
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Genome browser for vertebrate genomes. |
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An annotated collection of all publicly available DNA sequences. |
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A wiki-based platform for community curation of human long non-coding RNAs. |
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An integrated knowledge database dedicated to non-coding RNAs. |
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An integrated database of human annotated lncRNA transcripts. |
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Comprehensive annotations of eukaryotic long non-coding RNAs. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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A comprehensive, authoritative compendium of human genes and genetic phenotypes. |
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The catalogue of somatic mutations in cancer. |
