Basic Information
Regular Relationship :
Tissue/Cell lineOvcar3
SpecieHomo sapiens (human)
CitationHum Mol Genet 2015 Feb 1 24, 841-52 doi:10.1093/hmg/ddu502 PMID:25292198
Reference title
LncRNA-HOST2 regulates cell biological behaviors in epithelial ovarian cancer through a mechanism involving microRNA let-7b.
Experimental verification
qPCR, Western blot etc.
Functional description
The data showed that HOST2 was obviously upregulated in an EOCderived cell line, OVCAR-3, compared with the other tested cell lines, including MKN28, Huh-7, HepG2, McF-7,DU145, A357, MG63, Hep-2, ARK2 and Hela. HOST2 promotes tumor cell migration, invasion and proliferation in epithelial ovarian cancer by working in key aspetcs of biological behaviors.
Annotations
External Annotation for HOST2 |
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LncRNA-associated competing triplets and functions. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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Infer genomic variations that disturb lncRNA-associated ceRNA regulation.. |
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Provide and annotate disease or phenotype-associated variants in human long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) or their regulatory elements. |
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Providing cellular-specific lncRNA-associated ceRNA networks predicted via high-throughput analysis of single-cell genomic data. |
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Information on all annotated and predicted human genes. |
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Gene nomenclature, gene families and associated resources (genomic, proteomic, phenotypic information). |
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Genome browser for vertebrate genomes. |
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An annotated collection of all publicly available DNA sequences. |
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A wiki-based platform for community curation of human long non-coding RNAs. |
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An integrated knowledge database dedicated to non-coding RNAs. |
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An integrated database of human annotated lncRNA transcripts. |
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Comprehensive annotations of eukaryotic long non-coding RNAs. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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A comprehensive, authoritative compendium of human genes and genetic phenotypes. |
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The catalogue of somatic mutations in cancer. |
