Basic Information
Regular Relationship :
Phenotype/DiseaseSpecieGlioblastoma
CeRNA1ENST00000520186[LncRNA]
miRNAmiR-21[miRNA]
CeRNA2PPP3CA[mRNA]
Tissue/Cell lineGlioblastoma tissues
SpecieHomo sapiens (human)
CitationOncol Rep 2016 Nov 36, 2911-2925 doi:10.3892/or.2016.5070 PMID:27600337
Reference title
Identification and functional characterization of lncRNAs acting as ceRNA involved in the malignant progression of glioblastoma multiforme.
Experimental verification
microarray, qPCR etc.
Functional description
In our expression profling analysis, the lncRNA ENST00000520186, ENST00000559981, ENST00000547415 and ENST00000518554 were separately considered as the ceRNA of miR-15a, miR-21, miR-29b and miR-29c in GBM. So far, these ceRNAs have not been reported implicated in GBM. Four mRNAs may be regulated by these miRNAs and lncRNAs, the PPP3CA have been reported to be aberrantly expressed in other tumors, but have not been studied in GBM.
Annotations
External Annotation for ENST00000520186 |
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LncRNA-associated competing triplets and functions. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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Infer genomic variations that disturb lncRNA-associated ceRNA regulation.. |
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Provide and annotate disease or phenotype-associated variants in human long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) or their regulatory elements. |
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Providing cellular-specific lncRNA-associated ceRNA networks predicted via high-throughput analysis of single-cell genomic data. |
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Information on all annotated and predicted human genes. |
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Gene nomenclature, gene families and associated resources (genomic, proteomic, phenotypic information). |
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Genome browser for vertebrate genomes. |
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An annotated collection of all publicly available DNA sequences. |
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A wiki-based platform for community curation of human long non-coding RNAs. |
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An integrated knowledge database dedicated to non-coding RNAs. |
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An integrated database of human annotated lncRNA transcripts. |
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Comprehensive annotations of eukaryotic long non-coding RNAs. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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A comprehensive, authoritative compendium of human genes and genetic phenotypes. |
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The catalogue of somatic mutations in cancer. |
