Basic Information
Regular Relationship :
Phenotype/DiseaseSpecieHepatocellular Carcinoma
CeRNA1FGFR3-AS[LncRNA]
miRNAmiR-374a[miRNA]
CeRNA2P21[mRNA]
Tissue/Cell lineSmmc-7721, Bel-7404
SpecieHomo sapiens (human)
CitationOncol Res 2018 Sep 14 26, 1257-1265 doi:10.3727/096504018x15172756878992 PMID:29463348
Reference title
Long non-coding RNA FGFR3-AS1 promotes hepatocellular carcinoma carcinogenesis via modulating PI3K/AKT pathway.
Experimental verification
RT-qPCR, Western blot, in vitro knockdown
Functional description
FGFR3-AS1 knockdown significantly inhibited cell proliferation but induced apoptosis.Moreover,FGFR3-AS1 knockdown led to more HCC cells arrested in G0 stage. Besides, FGFR3-AS1 knockdown significantly inhibited cell migration and invasion. Additionally,we found that FGFR3-AS1 silence dramatically delayed tumor growth in vivo.In mechanism, we found FGFR3-AS1 silence decreased the activation of PI3K/AKT signaling pathway.LncRNAs could regulate cell proliferation,apoptosis, migration and invasion by sponging miRNAs or interacting with specific proteins.Furthermore, western blot (WB) results indicated that FGFR3-AS1 knockdown promoted the expression of P21 but inhibited CYCLIN D1 expression.
Annotations
External Annotation for FGFR3-AS |
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LncRNA-associated competing triplets and functions. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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Infer genomic variations that disturb lncRNA-associated ceRNA regulation.. |
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Provide and annotate disease or phenotype-associated variants in human long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) or their regulatory elements. |
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Providing cellular-specific lncRNA-associated ceRNA networks predicted via high-throughput analysis of single-cell genomic data. |
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Information on all annotated and predicted human genes. |
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Gene nomenclature, gene families and associated resources (genomic, proteomic, phenotypic information). |
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Genome browser for vertebrate genomes. |
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An annotated collection of all publicly available DNA sequences. |
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A wiki-based platform for community curation of human long non-coding RNAs. |
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An integrated knowledge database dedicated to non-coding RNAs. |
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An integrated database of human annotated lncRNA transcripts. |
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Comprehensive annotations of eukaryotic long non-coding RNAs. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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A comprehensive, authoritative compendium of human genes and genetic phenotypes. |
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The catalogue of somatic mutations in cancer. |
