Basic Information
Regular Relationship :
Tissue/Cell linePc3, Du145, And Lncap
SpecieHomo sapiens (human)
CitationTumour Biol 2016 Oct 14, 10.1007/s13277-016-5429-8 doi:10.1007/s13277-016-5429-8 PMID:27743383
Reference title
LncRNA GAS5 inhibits proliferation and progression of prostate cancer by targeting miR-103 through AKT/mTOR signaling pathway.
Experimental verification
qPCR, RNAi, Western blot, Dual-luciferase reporter assay, Cell proliferation assay, ISH etc.
Functional description
The lncRNA GAS5 levels were reduced significantly in the PCa tissues and cell lines. A low exposure of lncRNA GAS5 caused AKT/mTOR signaling pathway activation in PC3 cells. In addition, over-exposure of lncRNA GAS5 was proven to significantly decelerate PCa cell progression in vitro and tumor growth in vivo through inactivating the AKT/mTOR signaling pathway.In this research, the exposure levels of the main components of the AKT/mTOR signaling pathway, including AKT, mTOR, and S6K1, all of which are tumorrelated genes, were assessed at total and at phosphorylation protein levels in vitro and in vivo.
Annotations
External Annotation for GAS5 |
|
|---|---|
 |
LncRNA-associated competing triplets and functions. |
 |
Comprehensive experimentally supported associations between lncRNA and human cancer. |
 |
Infer genomic variations that disturb lncRNA-associated ceRNA regulation.. |
 |
Provide and annotate disease or phenotype-associated variants in human long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) or their regulatory elements. |
 |
Providing cellular-specific lncRNA-associated ceRNA networks predicted via high-throughput analysis of single-cell genomic data. |
 |
Information on all annotated and predicted human genes. |
 |
Gene nomenclature, gene families and associated resources (genomic, proteomic, phenotypic information). |
 |
Genome browser for vertebrate genomes. |
 |
An annotated collection of all publicly available DNA sequences. |
 |
A wiki-based platform for community curation of human long non-coding RNAs. |
 |
An integrated knowledge database dedicated to non-coding RNAs. |
 |
An integrated database of human annotated lncRNA transcripts. |
 |
Comprehensive annotations of eukaryotic long non-coding RNAs. |
 |
Comprehensive experimentally supported associations between lncRNA and human cancer. |
 |
A comprehensive, authoritative compendium of human genes and genetic phenotypes. |
 |
The catalogue of somatic mutations in cancer. |
