Basic Information
Regular Relationship :
Tissue/Cell lineU87, U251, Hek 293T
SpecieHomo sapiens (human)
CitationMol Ther 2016 Aug 24, 1199-215 doi:10.1038/mt.2016.71 PMID:27058823
Reference title
CRNDE Promotes Malignant Progression of Glioma by Attenuating miR-384/PIWIL4/STAT3 Axis.
Experimental verification
qPCR, RNAi, Western blot, RIP, Luciferase reporter assay, Cell proliferation assay etc.
Functional description
CRNDE overexpression facilitated cell proliferation, migration, and invasion, while inhibited glioma cells apoptosis. Moreover, CRNDE promoted cell malignant behavior by decreasing miR-384 expression. Knockdown of CRNDE combined with overexpression of miR-384 restrained tumor growth and exhibit high survival in nude mice.
Annotations
External Annotation for CRNDE |
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LncRNA-associated competing triplets and functions. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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Infer genomic variations that disturb lncRNA-associated ceRNA regulation.. |
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Provide and annotate disease or phenotype-associated variants in human long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) or their regulatory elements. |
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Providing cellular-specific lncRNA-associated ceRNA networks predicted via high-throughput analysis of single-cell genomic data. |
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Information on all annotated and predicted human genes. |
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Gene nomenclature, gene families and associated resources (genomic, proteomic, phenotypic information). |
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Genome browser for vertebrate genomes. |
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An annotated collection of all publicly available DNA sequences. |
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A wiki-based platform for community curation of human long non-coding RNAs. |
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An integrated knowledge database dedicated to non-coding RNAs. |
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An integrated database of human annotated lncRNA transcripts. |
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Comprehensive annotations of eukaryotic long non-coding RNAs. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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A comprehensive, authoritative compendium of human genes and genetic phenotypes. |
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The catalogue of somatic mutations in cancer. |
