Basic Information
Regular Relationship :
Phenotype/DiseaseSpecieHepatocellular Carcinoma
CeRNA1treRNA[LncRNA]
miRNAmiR-190a[miRNA]
CeRNA2SNAIL1[mRNA]
Tissue/Cell lineHepg2, Huh7
SpecieHomo sapiens (human)
CitationFEBS Lett 2015 Dec 21 589, 4079-87 doi:10.1016/j.febslet.2015.11.024 PMID:26608035
Reference title
miR-190a inhibits epithelial-mesenchymal transition of hepatoma cells via targeting the long non-coding RNA treRNA.
Experimental verification
qPCR, RNAi, Western blot, Dual-luciferase reporter assay etc.
Functional description
We further examined the expression profile of treRNA and miR-190a in 24 pairs of HCC tissues and adjacent normal tissues. miR-190a exhibited a significantly low expression in HCC tissues compared to adjacent normal tissues. Meanwhile, an elevated expression of treRNA was observed in HCC tissue compared to adjacent normal tissue.
Annotations
External Annotation for treRNA |
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LncRNA-associated competing triplets and functions. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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Infer genomic variations that disturb lncRNA-associated ceRNA regulation.. |
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Provide and annotate disease or phenotype-associated variants in human long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) or their regulatory elements. |
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Providing cellular-specific lncRNA-associated ceRNA networks predicted via high-throughput analysis of single-cell genomic data. |
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Information on all annotated and predicted human genes. |
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Gene nomenclature, gene families and associated resources (genomic, proteomic, phenotypic information). |
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Genome browser for vertebrate genomes. |
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An annotated collection of all publicly available DNA sequences. |
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A wiki-based platform for community curation of human long non-coding RNAs. |
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An integrated knowledge database dedicated to non-coding RNAs. |
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An integrated database of human annotated lncRNA transcripts. |
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Comprehensive annotations of eukaryotic long non-coding RNAs. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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A comprehensive, authoritative compendium of human genes and genetic phenotypes. |
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The catalogue of somatic mutations in cancer. |
