Basic Information
Regular Relationship :
Phenotype/DiseaseSpecieMuscle Differentiation
CeRNA1linc-MD1[LncRNA]
miRNAmiR-133[miRNA]
CeRNA2MEF2C[mRNA]
Tissue/Cell lineMyoblasts
SpecieMus musculus (mouse)
CitationCell 2011 Oct 14 147, 358-69 doi:10.1016/j.cell.2011.09.028 PMID:22000014
Reference title
A long noncoding RNA controls muscle differentiation by functioning as a competing endogenous RNA
Experimental verification
Northern blot;Western blot;qRT-PCR;luciferase reporter assays
Functional description
linc-MD1 "sponges" miR-133 and miR-133 [corrected] to regulate the expression of MAML1 and MEF2C, transcription factors that activate muscle-specific gene expression.
Annotations
External Annotation for linc-MD1 |
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LncRNA-associated competing triplets and functions. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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Infer genomic variations that disturb lncRNA-associated ceRNA regulation.. |
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Provide and annotate disease or phenotype-associated variants in human long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) or their regulatory elements. |
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Providing cellular-specific lncRNA-associated ceRNA networks predicted via high-throughput analysis of single-cell genomic data. |
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Information on all annotated and predicted human genes. |
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Gene nomenclature, gene families and associated resources (genomic, proteomic, phenotypic information). |
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Genome browser for vertebrate genomes. |
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An annotated collection of all publicly available DNA sequences. |
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A wiki-based platform for community curation of human long non-coding RNAs. |
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An integrated knowledge database dedicated to non-coding RNAs. |
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An integrated database of human annotated lncRNA transcripts. |
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Comprehensive annotations of eukaryotic long non-coding RNAs. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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A comprehensive, authoritative compendium of human genes and genetic phenotypes. |
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The catalogue of somatic mutations in cancer. |
