Basic Information
Regular Relationship :
Phenotype/DiseaseSpecieColorectal Cancer
CeRNA1LINC00152[LncRNA]
miRNAmiR-376c-3p[miRNA]
CeRNA2BCL-2[mRNA]
Tissue/Cell lineCaco2, Hct-116, Ht-29, Sw480, And Sw620
SpecieHomo sapiens (human)
CitationAm J Transl Res 2016 8, 5286-5297, PMID:28078002
Reference title
LncRNA-LINC00152 down-regulated by miR-376c-3p restricts viability and promotes apoptosis of colorectal cancer cells.
Experimental verification
qPCR, Flow cytometry assay, CCK-8 assay etc.
Functional description
We found that LINC00152 expression was significantly decreased in CRC tissues and CRC cell lines. Overexpression of LINC00152 resulted in decreased cell viability and increased apoptosis in CSC cell lines. Interestingly, miR-376c-3p down-regulated the expression of LINC00152 in CSC cells. In addition, miR-376c-3p suppressed the effect of LINC00152 on the viability and apoptosis of CSC cells.
Annotations
External Annotation for LINC00152 |
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LncRNA-associated competing triplets and functions. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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Infer genomic variations that disturb lncRNA-associated ceRNA regulation.. |
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Provide and annotate disease or phenotype-associated variants in human long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) or their regulatory elements. |
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Providing cellular-specific lncRNA-associated ceRNA networks predicted via high-throughput analysis of single-cell genomic data. |
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Information on all annotated and predicted human genes. |
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Gene nomenclature, gene families and associated resources (genomic, proteomic, phenotypic information). |
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Genome browser for vertebrate genomes. |
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An annotated collection of all publicly available DNA sequences. |
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A wiki-based platform for community curation of human long non-coding RNAs. |
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An integrated knowledge database dedicated to non-coding RNAs. |
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An integrated database of human annotated lncRNA transcripts. |
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Comprehensive annotations of eukaryotic long non-coding RNAs. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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A comprehensive, authoritative compendium of human genes and genetic phenotypes. |
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The catalogue of somatic mutations in cancer. |
