Basic Information
Regular Relationship :
Tissue/Cell lineMcf-7, Bcap-37 And Mdamb-435S
SpecieHomo sapiens (human)
CitationOncotarget 2016 Mar 29 7, 16205-16 doi:10.18632/oncotarget.7578 PMID:26918449
Reference title
miR-124 downregulation leads to breast cancer progression via LncRNA-MALAT1 regulation and CDK4/E2F1 signal activation.
Experimental verification
qPCR, RNAi, Western blot, Dual-luciferase reporter assay etc.
Functional description
We also found that MALAT1 was increased in most breast cancer cells. In contrast, miR-124 was downregulated in the MCF-7 cells with MALAT1 overexpression. We found that MALAT1 expression had no effect in breast cancer cells treated with the miR-124 mimic or miR-124 inhibitor. Taken together, our results reveal that MALAT1 may act as an endogenous potent regulator that reduces miR-124 expression.
Annotations
External Annotation for MALAT1 |
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LncRNA-associated competing triplets and functions. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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Infer genomic variations that disturb lncRNA-associated ceRNA regulation.. |
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Provide and annotate disease or phenotype-associated variants in human long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) or their regulatory elements. |
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Providing cellular-specific lncRNA-associated ceRNA networks predicted via high-throughput analysis of single-cell genomic data. |
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Information on all annotated and predicted human genes. |
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Gene nomenclature, gene families and associated resources (genomic, proteomic, phenotypic information). |
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Genome browser for vertebrate genomes. |
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An annotated collection of all publicly available DNA sequences. |
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A wiki-based platform for community curation of human long non-coding RNAs. |
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An integrated knowledge database dedicated to non-coding RNAs. |
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An integrated database of human annotated lncRNA transcripts. |
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Comprehensive annotations of eukaryotic long non-coding RNAs. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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A comprehensive, authoritative compendium of human genes and genetic phenotypes. |
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The catalogue of somatic mutations in cancer. |
