LncACTdb 3.0

miRNA

miR-1[miRNA]

CeRNA2

KRAS[mRNA]

Tissue/Cell line

Breast Cancer tissues

Specie

Homo sapiens (human)

Citation

Int J Biol Macromol 2015 Nov 81, 491-7 doi:10.1016/j.ijbiomac.2015.08.016 PMID:26275461

Reference title

Hsa-miR-1 suppresses breast cancer development by down-regulating K-ras and long non-coding RNA MALAT1

Experimental verification

qPCR, Western blot, Luciferase reporter assay etc.

Functional description

The effects of up-regulation of miR-1 were similar to that of silencing K-RAS and MALAT1 in breast cancer cells

External Annotation for MALAT1
	LncRNA-associated competing triplets and functions.
	Comprehensive experimentally supported associations between lncRNA and human cancer.
	Infer genomic variations that disturb lncRNA-associated ceRNA regulation..
	Provide and annotate disease or phenotype-associated variants in human long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) or their regulatory elements.
	Providing cellular-specific lncRNA-associated ceRNA networks predicted via high-throughput analysis of single-cell genomic data.
	Information on all annotated and predicted human genes.
	Gene nomenclature, gene families and associated resources (genomic, proteomic, phenotypic information).
	Genome browser for vertebrate genomes.
	An annotated collection of all publicly available DNA sequences.
	A wiki-based platform for community curation of human long non-coding RNAs.
	An integrated knowledge database dedicated to non-coding RNAs.
	An integrated database of human annotated lncRNA transcripts.
	Comprehensive annotations of eukaryotic long non-coding RNAs.
	Comprehensive experimentally supported associations between lncRNA and human cancer.
	A comprehensive, authoritative compendium of human genes and genetic phenotypes.
	The catalogue of somatic mutations in cancer.

Detail (Experimental CeRNA)