Basic Information
Regular Relationship :
Phenotype/DiseaseSpecieMuscle Differentiation And Regeneration
CeRNA1H19[Host gene]
miRNAmiR-675-3p[miRNA]
CeRNA2Smad[mRNA]
Tissue/Cell lineMyoblast Cells And Mouse Satellite Cells
SpecieMus musculus (mouse)
CitationGenes Dev 2014 Mar 1 28, 491-501 doi:10.1101/gad.234419.113 PMID:24532688
Reference title
The H19 long noncoding RNA gives rise to microRNAs miR-675-3p and miR-675-5p to promote skeletal muscle differentiation and regeneration
Experimental verification
Western blot;qRT-PCR;luciferase reporter assays
Functional description
H19 exon1 encodes two conserved microRNAs, miR-675-3p andmiR-675-5p, both of which are induced during skeletal muscle differentiation.miR-675-3p and miR-675-5p functionby directly targeting and down-regulating the anti-differentiation Smadtranscription factors critical for the bone morphogenetic protein (BMP) pathwayand the DNA replication initiation factor Cdc6.
Annotations
External Annotation for H19 |
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LncRNA-associated competing triplets and functions. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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Infer genomic variations that disturb lncRNA-associated ceRNA regulation.. |
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Provide and annotate disease or phenotype-associated variants in human long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) or their regulatory elements. |
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Providing cellular-specific lncRNA-associated ceRNA networks predicted via high-throughput analysis of single-cell genomic data. |
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Information on all annotated and predicted human genes. |
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Gene nomenclature, gene families and associated resources (genomic, proteomic, phenotypic information). |
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Genome browser for vertebrate genomes. |
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An annotated collection of all publicly available DNA sequences. |
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A wiki-based platform for community curation of human long non-coding RNAs. |
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An integrated knowledge database dedicated to non-coding RNAs. |
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An integrated database of human annotated lncRNA transcripts. |
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Comprehensive annotations of eukaryotic long non-coding RNAs. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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A comprehensive, authoritative compendium of human genes and genetic phenotypes. |
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The catalogue of somatic mutations in cancer. |
