Basic Information
Regular Relationship :
Phenotype/DiseaseSpecieBladder Cancer
CeRNA1MALAT1[LncRNA]
miRNAmiR-125b[miRNA]
CeRNA2SIRT7[mRNA]
Tissue/Cell lineT24, 5737, Sv-Huc-1, Hek 293T
SpecieHomo sapiens (human)
CitationFEBS Lett 2013 Oct 25, 10.1016/j.febslet.2013.10.023 doi:10.1016/j.febslet.2013.10.023 PMID:24512851
Reference title
Hsa-miR-125b suppresses bladder cancer development by down-regulating oncogene SIRT7 and oncogenic long noncoding RNA MALAT1.
Experimental verification
qPCR, Western blot, ChIP, Luciferase reporter assay, Cell proliferation assay etc.
Functional description
Hsa-miR-125b was down-regulated in bladder cancer compared with matched normal urothelium. Both SIRT7 and MALAT1 were up-regulated in bladder cancer compared with matched normal urothelium. Upregulation of hsa-miR-125b or downregulation of SIRT7 inhibited proliferation, motility and increased apoptosis.
Annotations
External Annotation for MALAT1 |
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LncRNA-associated competing triplets and functions. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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Infer genomic variations that disturb lncRNA-associated ceRNA regulation.. |
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Provide and annotate disease or phenotype-associated variants in human long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) or their regulatory elements. |
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Providing cellular-specific lncRNA-associated ceRNA networks predicted via high-throughput analysis of single-cell genomic data. |
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Information on all annotated and predicted human genes. |
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Gene nomenclature, gene families and associated resources (genomic, proteomic, phenotypic information). |
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Genome browser for vertebrate genomes. |
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An annotated collection of all publicly available DNA sequences. |
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A wiki-based platform for community curation of human long non-coding RNAs. |
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An integrated knowledge database dedicated to non-coding RNAs. |
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An integrated database of human annotated lncRNA transcripts. |
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Comprehensive annotations of eukaryotic long non-coding RNAs. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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A comprehensive, authoritative compendium of human genes and genetic phenotypes. |
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The catalogue of somatic mutations in cancer. |
