Basic Information
Regular Relationship :
Phenotype/DiseaseSpecieHepatocellular Carcinoma
CeRNA1GTL2[LncRNA]
miRNAmiR-29[miRNA]
CeRNA2DNMT1[mRNA]
Tissue/Cell lineHCC cell lines and human HCC tissue
SpecieMus musculus (mouse)
CitationOncogene 2011 Nov 24 30, 4750-6 doi:10.1038/onc.2011.193 PMID:21625215
Reference title
microRNA-29 can regulate expression of the long non-coding RNA gene MEG3 in hepatocellular cancer.
Experimental verification
microarray, qPCR etc.
Functional description
The expression of miR-29a in several HCC cell lines and human HCC tissues correlated with expression of MEG3 with a P-value of 0.04. Over-expression of miR-29a in HCC cells increased MEG3 expression. The effects of miR-29a on MEG3 expression were further evaluated in vivo using genetically engineered mice with a hepatocyte-specific knockout of miR-29 a/b1. The murine analog of MEG3, named GTL2 is located on chromosome 12. Compared with the expression in liver tissues in wild-type mice, GTL2 expression was remarkably reduced in liver tissues from miR-29 KO mice under basal conditions. All together these studies suggest that miR-29 may indirectly modulate MEG3/GTL2 expression by acting on the methylation machinery.
Annotations
External Annotation for GTL2 |
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LncRNA-associated competing triplets and functions. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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Infer genomic variations that disturb lncRNA-associated ceRNA regulation.. |
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Provide and annotate disease or phenotype-associated variants in human long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) or their regulatory elements. |
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Providing cellular-specific lncRNA-associated ceRNA networks predicted via high-throughput analysis of single-cell genomic data. |
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Information on all annotated and predicted human genes. |
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Gene nomenclature, gene families and associated resources (genomic, proteomic, phenotypic information). |
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Genome browser for vertebrate genomes. |
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An annotated collection of all publicly available DNA sequences. |
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A wiki-based platform for community curation of human long non-coding RNAs. |
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An integrated knowledge database dedicated to non-coding RNAs. |
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An integrated database of human annotated lncRNA transcripts. |
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Comprehensive annotations of eukaryotic long non-coding RNAs. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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A comprehensive, authoritative compendium of human genes and genetic phenotypes. |
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The catalogue of somatic mutations in cancer. |
