Basic Information
Regular Relationship :
Tissue/Cell lineHct116
SpecieHomo sapiens (human)
CitationEMBO Rep 2016 Aug 17, 1204-20 doi:10.15252/embr.201642067 PMID:27317567
Reference title
LncRNA-MIF, a c-Myc-activated long non-coding RNA, suppresses glycolysis by promoting Fbxw10-mediated c-Myc degradation
Experimental verification
qPCR, Luciferase reporter assay etc.
Functional description
In this study, we demonstrate that lncRNA�IF (Myc inhibitory factor), which is transcribed by c�yc, is able to reduce c�yc expression. Mechanistically, lncRNA�IF competes with coding mRNA Fbxw7 for miR586 and relieves the inhibitory effect of miR586 on Fbxw7, thereby leading to increased Fbxw10 expression and decreased c�yc level.
Annotations
External Annotation for MIF |
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LncRNA-associated competing triplets and functions. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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Infer genomic variations that disturb lncRNA-associated ceRNA regulation.. |
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Provide and annotate disease or phenotype-associated variants in human long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) or their regulatory elements. |
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Providing cellular-specific lncRNA-associated ceRNA networks predicted via high-throughput analysis of single-cell genomic data. |
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Information on all annotated and predicted human genes. |
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Gene nomenclature, gene families and associated resources (genomic, proteomic, phenotypic information). |
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Genome browser for vertebrate genomes. |
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An annotated collection of all publicly available DNA sequences. |
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A wiki-based platform for community curation of human long non-coding RNAs. |
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An integrated knowledge database dedicated to non-coding RNAs. |
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An integrated database of human annotated lncRNA transcripts. |
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Comprehensive annotations of eukaryotic long non-coding RNAs. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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A comprehensive, authoritative compendium of human genes and genetic phenotypes. |
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The catalogue of somatic mutations in cancer. |
