Basic Information
Regular Relationship :
Phenotype/DiseaseSpecieOssification Of The Ligamentum Flavum
CeRNA1RP11-523G9.3[LncRNA]
miRNAmiR-19b-3p[miRNA]
CeRNA2RUNX2[mRNA]
Tissue/Cell linehMSCs
SpecieHomo sapiens (human)
CitationMol Ther Nucleic Acids 2018 Sep 7 12, 872-883 doi:10.1016/j.omtn.2018.07.018 PMID:30161026
Reference title
A Transcriptome-Level Study Identifies Changing Expression Profiles for Ossification of the Ligamentum Flavum of the Spine
Experimental verification
qPCR
Functional description
Given the evidence that the deregulated lncRNAs ENST00000608133 and ENST00000599584, which were actually targets of miR-19b-3p, are related to ossification by regulation, at least, of RUNX2, which is also regulated by miR-19b-3p and circ_0050139, we conclude that the deregulated miRNAs, lncRNAs, and circRNAs regulate ossification-associated genes. Furthermore, we confirmed the co-regulation with experiments showing that overexpression of miR-19b-3p downregulates the levels of ENST00000608133, ENST00000599584, and circ_0050139.
Annotations
External Annotation for RP11-523G9.3 |
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LncRNA-associated competing triplets and functions. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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Infer genomic variations that disturb lncRNA-associated ceRNA regulation.. |
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Provide and annotate disease or phenotype-associated variants in human long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) or their regulatory elements. |
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Providing cellular-specific lncRNA-associated ceRNA networks predicted via high-throughput analysis of single-cell genomic data. |
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Information on all annotated and predicted human genes. |
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Gene nomenclature, gene families and associated resources (genomic, proteomic, phenotypic information). |
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Genome browser for vertebrate genomes. |
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An annotated collection of all publicly available DNA sequences. |
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A wiki-based platform for community curation of human long non-coding RNAs. |
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An integrated knowledge database dedicated to non-coding RNAs. |
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An integrated database of human annotated lncRNA transcripts. |
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Comprehensive annotations of eukaryotic long non-coding RNAs. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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A comprehensive, authoritative compendium of human genes and genetic phenotypes. |
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The catalogue of somatic mutations in cancer. |
