Basic Information
Regular Relationship :
Phenotype/DiseaseSpecieCervical Cancer
CeRNA1NEAT1[LncRNA]
miRNAmiR-9-5p[miRNA]
CeRNA2PTEN?[mRNA]
Tissue/Cell lineHela Cells
SpecieHomo sapiens (human)
CitationBiochem Cell Biol 2019 Apr 97, 100-108 doi:10.1139/bcb-2018-0111 PMID:30096244
Reference title
Long noncoding RNA NEAT1 promoted the growth of cervical cancer cells via sponging miR-9-5p.
Experimental verification
qPCR
Functional description
Overexpression of NEAT1 promoted the proliferation and migration of cervical cancer cells. Molecular study uncovered that NEAT1 functioned as competitive endogenous RNA (ceRNA) to bind miR-9-5p and suppress the expression of miR-9-5p. Consistently, highly expressed NEAT1 attenuated the inhibitory effect of miR-9-5p on the expression of PTEN and POU2F1, which were the targets of miR-9-5p. In agreement with the negative regulation of NEAT1 on miR-9-5p, restoration of miR-9-5p inhibited the promotion of NEAT1 on the growth of cervical cancer cells.
Annotations
External Annotation for NEAT1 |
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LncRNA-associated competing triplets and functions. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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Infer genomic variations that disturb lncRNA-associated ceRNA regulation.. |
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Provide and annotate disease or phenotype-associated variants in human long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) or their regulatory elements. |
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Providing cellular-specific lncRNA-associated ceRNA networks predicted via high-throughput analysis of single-cell genomic data. |
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Information on all annotated and predicted human genes. |
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Gene nomenclature, gene families and associated resources (genomic, proteomic, phenotypic information). |
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Genome browser for vertebrate genomes. |
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An annotated collection of all publicly available DNA sequences. |
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A wiki-based platform for community curation of human long non-coding RNAs. |
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An integrated knowledge database dedicated to non-coding RNAs. |
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An integrated database of human annotated lncRNA transcripts. |
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Comprehensive annotations of eukaryotic long non-coding RNAs. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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A comprehensive, authoritative compendium of human genes and genetic phenotypes. |
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The catalogue of somatic mutations in cancer. |
