Basic Information
Regular Relationship :
Phenotype/DiseaseSpecieCardiac Hypertrophy
CeRNA1CHRF[LncRNA]
miRNAmiR-489[miRNA]
CeRNA2Myd88[mRNA]
Tissue/Cell lineCardiac Fibroblasts
SpecieMus musculus (mouse)
CitationCirc Res 2014 Apr 25 114, 1377-88 doi:10.1161/circresaha.114.302476 PMID:24557880
Reference title
A Long Noncoding RNA, CHRF Regulates Cardiac Hypertrophy by Targeting miR-489
Experimental verification
Western blot;qRT-PCR;luciferase reporter assays
Functional description
we explored the molecular mechanism by which miR-489 expression is regulated, and found that a long non-codingRNA that we named cardiac hypertrophy related factor (CHRF) acts as an endogenous sponge of miR-489, which downregulates miR-489 expression levels. We identified miR-489 and lncRNAs (cardiac hypertrophy related factor, CHRF) from hypertrophic cardiomyocytes. Here, we tested the hypothesis that miR-489 and CHRF can participate in the regulation of cardiac hypertrophy in vivo and in vitro.
Annotations
External Annotation for CHRF |
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LncRNA-associated competing triplets and functions. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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Infer genomic variations that disturb lncRNA-associated ceRNA regulation.. |
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Provide and annotate disease or phenotype-associated variants in human long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) or their regulatory elements. |
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Providing cellular-specific lncRNA-associated ceRNA networks predicted via high-throughput analysis of single-cell genomic data. |
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Information on all annotated and predicted human genes. |
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Gene nomenclature, gene families and associated resources (genomic, proteomic, phenotypic information). |
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Genome browser for vertebrate genomes. |
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An annotated collection of all publicly available DNA sequences. |
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A wiki-based platform for community curation of human long non-coding RNAs. |
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An integrated knowledge database dedicated to non-coding RNAs. |
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An integrated database of human annotated lncRNA transcripts. |
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Comprehensive annotations of eukaryotic long non-coding RNAs. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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A comprehensive, authoritative compendium of human genes and genetic phenotypes. |
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The catalogue of somatic mutations in cancer. |
