LncACTdb 3.0

miRNA

CeRNA2

NF1[mRNA]

Tissue/Cell line

BEAS-2B, A549 and HCC823

Specie

Homo sapiens (human)

Citation

Eur Rev Med Pharmacol Sci 2018 Sep 22, 5946-5953 doi:10.26355/eurrev_201809_15925 PMID:30280776

Reference title

LncRNA H19 serves as a ceRNA and participates in non-small cell lung cancer development by regulating microRNA-107

Experimental verification

qPCR, Western blot, Luciferase reporter assay etc.

Functional description

H19 is highly expressed in NSCLC, which promotes NSCLC development by regulating NF1 via competitive binding to microRNA-107.

External Annotation for H19
	LncRNA-associated competing triplets and functions.
	Comprehensive experimentally supported associations between lncRNA and human cancer.
	Infer genomic variations that disturb lncRNA-associated ceRNA regulation..
	Provide and annotate disease or phenotype-associated variants in human long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) or their regulatory elements.
	Providing cellular-specific lncRNA-associated ceRNA networks predicted via high-throughput analysis of single-cell genomic data.
	Information on all annotated and predicted human genes.
	Gene nomenclature, gene families and associated resources (genomic, proteomic, phenotypic information).
	Genome browser for vertebrate genomes.
	An annotated collection of all publicly available DNA sequences.
	A wiki-based platform for community curation of human long non-coding RNAs.
	An integrated knowledge database dedicated to non-coding RNAs.
	An integrated database of human annotated lncRNA transcripts.
	Comprehensive annotations of eukaryotic long non-coding RNAs.
	Comprehensive experimentally supported associations between lncRNA and human cancer.
	A comprehensive, authoritative compendium of human genes and genetic phenotypes.
	The catalogue of somatic mutations in cancer.

Detail (Experimental CeRNA)