Basic Information
Regular Relationship :
Phenotype/DiseaseSpecieCardiac Hypertrophy
CeRNA1AdDecoy133[Artifically engineered RNA]
miRNAmiR-133[miRNA]
CeRNA2NelfA[mRNA]
Tissue/Cell lineHeart Tissues
SpecieMus musculus (mouse)
CitationNat Med 2007 May 13, 613-8 doi:10.1038/nm1582 PMID:17468766
Reference title
MicroRNA-133 controls cardiac hypertrophy
Experimental verification
Western blot;qRT-PCR;luciferase reporter assays
Functional description
Suppression of miR-133 by ‘decoy’ sequences induced hypertrophy,which was more pronounced than that after stimulation with conventional inducers of hypertrophy. In vivo inhibition of miR-133 by a single infusion of an antagomir caused markedand sustained cardiac hypertrophy.
Annotations
External Annotation for AdDecoy133 |
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LncRNA-associated competing triplets and functions. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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Infer genomic variations that disturb lncRNA-associated ceRNA regulation.. |
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Provide and annotate disease or phenotype-associated variants in human long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) or their regulatory elements. |
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Providing cellular-specific lncRNA-associated ceRNA networks predicted via high-throughput analysis of single-cell genomic data. |
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Information on all annotated and predicted human genes. |
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Gene nomenclature, gene families and associated resources (genomic, proteomic, phenotypic information). |
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Genome browser for vertebrate genomes. |
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An annotated collection of all publicly available DNA sequences. |
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A wiki-based platform for community curation of human long non-coding RNAs. |
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An integrated knowledge database dedicated to non-coding RNAs. |
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An integrated database of human annotated lncRNA transcripts. |
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Comprehensive annotations of eukaryotic long non-coding RNAs. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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A comprehensive, authoritative compendium of human genes and genetic phenotypes. |
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The catalogue of somatic mutations in cancer. |
