Basic Information
Regular Relationship :
Phenotype/DiseaseSpeciePancreatic Cancer
CeRNA1OIP5-AS1[LncRNA]
miRNAmiR-143-3p[miRNA]
CeRNA2ITGA6[mRNA]
Tissue/Cell lineC33A, SiHa, HeLa, CaSki, ME180
SpecieHomo sapiens (human)
CitationJ Cell Biochem 2019 Jan 120, 907-916 doi:10.1002/jcb.27454 PMID:30188591
Reference title
Long noncoding RNA opa-interacting protein 5 antisense transcript 1 promotes proliferation and invasion through elevating integrin α6 expression by sponging miR-143-3p in cervical cancer
Experimental verification
qPCR, Western blot, Luciferase reporter assay etc.
Functional description
In conclusion, we demonstrated that OIP5〢S1 promoted proliferation and invasion of CC cells via increasing the ITGA6 expression by sponging miR1433p, which might be an effective therapeutic target for the treatment of patients with CC
Annotations
External Annotation for OIP5-AS1 |
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LncRNA-associated competing triplets and functions. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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Infer genomic variations that disturb lncRNA-associated ceRNA regulation.. |
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Provide and annotate disease or phenotype-associated variants in human long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) or their regulatory elements. |
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Providing cellular-specific lncRNA-associated ceRNA networks predicted via high-throughput analysis of single-cell genomic data. |
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Information on all annotated and predicted human genes. |
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Gene nomenclature, gene families and associated resources (genomic, proteomic, phenotypic information). |
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Genome browser for vertebrate genomes. |
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An annotated collection of all publicly available DNA sequences. |
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A wiki-based platform for community curation of human long non-coding RNAs. |
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An integrated knowledge database dedicated to non-coding RNAs. |
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An integrated database of human annotated lncRNA transcripts. |
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Comprehensive annotations of eukaryotic long non-coding RNAs. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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A comprehensive, authoritative compendium of human genes and genetic phenotypes. |
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The catalogue of somatic mutations in cancer. |
