LncACTdb 3.0

miRNA

CeRNA2

HEY2[mRNA]

Tissue/Cell line

A549, SK-MES-1, Calu-3 and H1299

Specie

Homo sapiens (human)

Citation

Biomed Pharmacother 2018 Nov 107, 1540-1547 doi:10.1016/j.biopha.2018.08.105 PMID:30257372

Reference title

LncRNA PRNCR1 interacts with HEY2 to abolish miR-448-mediated growth inhibition in non-small cell lung cancer

Experimental verification

qPCR, Western blot, Luciferase reporter assay etc.

Functional description

All mechanism experiments revealed that lncRNA PRNCR1 exerted ceRNA function in NSCLC by regulating miR-448 and HEY2.

External Annotation for PRNCR1
	LncRNA-associated competing triplets and functions.
	Comprehensive experimentally supported associations between lncRNA and human cancer.
	Infer genomic variations that disturb lncRNA-associated ceRNA regulation..
	Provide and annotate disease or phenotype-associated variants in human long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) or their regulatory elements.
	Providing cellular-specific lncRNA-associated ceRNA networks predicted via high-throughput analysis of single-cell genomic data.
	Information on all annotated and predicted human genes.
	Gene nomenclature, gene families and associated resources (genomic, proteomic, phenotypic information).
	Genome browser for vertebrate genomes.
	An annotated collection of all publicly available DNA sequences.
	A wiki-based platform for community curation of human long non-coding RNAs.
	An integrated knowledge database dedicated to non-coding RNAs.
	An integrated database of human annotated lncRNA transcripts.
	Comprehensive annotations of eukaryotic long non-coding RNAs.
	Comprehensive experimentally supported associations between lncRNA and human cancer.
	A comprehensive, authoritative compendium of human genes and genetic phenotypes.
	The catalogue of somatic mutations in cancer.

Detail (Experimental CeRNA)