LncACTdb 3.0

miRNA

miR-21[miRNA]

CeRNA2

PTEN[mRNA]

Tissue/Cell line

786-O, ACHN, and SN12PM6

Specie

Homo sapiens (human)

Citation

Mol Cancer Ther 2014 Dec 13, 3086-97 doi:10.1158/1535-7163.Mct-14-0245 PMID:25249556

Reference title

Pseudogene PTENP1 functions as a competing endogenous RNA to suppress clear-cell renal cell carcinoma progression

Experimental verification

qPCR, Western blot, Luciferase reporter assay etc.

Functional description

These results suggest that PTENP1 functions as a competing endogenous RNA (ceRNA) in ccRCC to suppress cancer progression

External Annotation for PTENP1
	LncRNA-associated competing triplets and functions.
	Comprehensive experimentally supported associations between lncRNA and human cancer.
	Infer genomic variations that disturb lncRNA-associated ceRNA regulation..
	Provide and annotate disease or phenotype-associated variants in human long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) or their regulatory elements.
	Providing cellular-specific lncRNA-associated ceRNA networks predicted via high-throughput analysis of single-cell genomic data.
	Information on all annotated and predicted human genes.
	Gene nomenclature, gene families and associated resources (genomic, proteomic, phenotypic information).
	Genome browser for vertebrate genomes.
	An annotated collection of all publicly available DNA sequences.
	A wiki-based platform for community curation of human long non-coding RNAs.
	An integrated knowledge database dedicated to non-coding RNAs.
	An integrated database of human annotated lncRNA transcripts.
	Comprehensive annotations of eukaryotic long non-coding RNAs.
	Comprehensive experimentally supported associations between lncRNA and human cancer.
	A comprehensive, authoritative compendium of human genes and genetic phenotypes.
	The catalogue of somatic mutations in cancer.

Detail (Experimental CeRNA)